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Table 2 Uni- and multivariable predictors of VTE risk in localized CRC

From: Patterns of venous thromboembolism risk in patients with localized colorectal cancer undergoing adjuvant chemotherapy or active surveillance: an observational cohort study

  Univariable analysis Multivariable analysis adjusting for BMI
Variable Subdistribution hazard ratio (SHR) 95% CI p Subdistribution hazard ratio (SHR) 95% CI p
Age at diagnosis (per 5 years increase) 0.93 0.81–1.06 0.29 0.85 0.70–1.02 0.09
BMI (per 5 kg/m2 increase) 1.57 1.23–2.02 <0.0001 N/A N/A N/A
KI at diagnosis
 100% Ref. Ref. Ref. Ref. Ref. Ref.
 < 100% 0.28 0.06–1.35 0.11 0.31 0.07–1.48 0.14
 Family history of CRC 1.00 0.12–8.23 0.99 1.19 0.14–10.22 0.87
 Smoker or Ex-Smoker 1.64 0.44–6.09 0.46 1.71 0.43–6.85 0.45
Tumor localization
 Non-rectal Ref. Ref. Ref. Ref. Ref. Ref.
 Rectal 0.97 0.35–2.68 0.95 1.74 0.5–6.11 0.39
TNM – T
 T1 & T2 & T3 Ref. Ref. Ref. Ref. Ref. Ref.
 T4 0.95 0.27–3.36 0.94 0.53 0.06–4.80 0.57
TNM - N
 N0 Ref. Ref. Ref. Ref. Ref. Ref.
 N1 & N2 0.85 0.29–2.46 0.76 1.14 0.28–4.66 0.86
Stage
 Stage II Ref. Ref. Ref. Ref. Ref. Ref.
 Stage III 1.15 0.37–3.59 0.81 1.75 0.40–7.63 0.46
Adjuvant chemotherapy 0.98 0.33–2.88 0.97 1.18 0.27–5.24 0.23
  1. Abbreviations: SHR Subdistribution hazard ratio, 95% CI 95% confidence interval, KI Karnofsky Index, TNM Tumor Node Metastasis classification, BMI Body mass index, CRC Colorectal cancer