Patterns of venous thromboembolism risk in patients with localized colorectal cancer undergoing adjuvant chemotherapy or active surveillance: an observational cohort study

Table 2 Uni- and multivariable predictors of VTE risk in localized CRC

	Univariable analysis			Multivariable analysis adjusting for BMI
Variable	Subdistribution hazard ratio (SHR)	95% CI	p	Subdistribution hazard ratio (SHR)	95% CI	p
Age at diagnosis (per 5 years increase)	0.93	0.81–1.06	0.29	0.85	0.70–1.02	0.09
BMI (per 5 kg/m² increase)	1.57	1.23–2.02	<0.0001	N/A	N/A	N/A
KI at diagnosis
100%	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
< 100%	0.28	0.06–1.35	0.11	0.31	0.07–1.48	0.14
Family history of CRC	1.00	0.12–8.23	0.99	1.19	0.14–10.22	0.87
Smoker or Ex-Smoker	1.64	0.44–6.09	0.46	1.71	0.43–6.85	0.45
Tumor localization
Non-rectal	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Rectal	0.97	0.35–2.68	0.95	1.74	0.5–6.11	0.39
TNM – T
T1 & T2 & T3	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
T4	0.95	0.27–3.36	0.94	0.53	0.06–4.80	0.57
TNM - N
N0	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
N1 & N2	0.85	0.29–2.46	0.76	1.14	0.28–4.66	0.86
Stage
Stage II	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Stage III	1.15	0.37–3.59	0.81	1.75	0.40–7.63	0.46
Adjuvant chemotherapy	0.98	0.33–2.88	0.97	1.18	0.27–5.24	0.23

Abbreviations: SHR Subdistribution hazard ratio, 95% CI 95% confidence interval, KI Karnofsky Index, TNM Tumor Node Metastasis classification, BMI Body mass index, CRC Colorectal cancer

ISSN: 1471-2407