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Table 1 Baseline characteristics of the study population

From: Patterns of venous thromboembolism risk in patients with localized colorectal cancer undergoing adjuvant chemotherapy or active surveillance: an observational cohort study

Variable n (%miss.) Overall (n = 516) No VTE (n = 501) VTE (n = 15) p*
Age at diagnosis (years) 516 (0.0%) 65.1 [55.3–72.3] 65.2 [55.2–72.4] 62.1 [57.0–67.1] 0.28
BMI (kg/m2) 413 (20.0%) 25.5 [23.0–28.7] 25.4 [22.8–28.7] 29.9 [25.6–36.6] 0.005
Karnofsky Index at diagnosis (%) 347 (32.8%) / / / 0.23
  ≤ 80% / 57 (16.4%) 56 (16.6%) 1 (11.1%) /
 90% / 116 (33.4%) 115 (34.0%) 1 (11.1%) /
 100% / 174 (50.1%) 167 (49.4%) 7 (77.8%) /
Family history of CRC 256 (50.4%) / / / 0.76
 No family history / 217 (84.8%) 211 (84.7%) 6 (85.7%) /
 1st degree relative / 25 (9.8%) 24 (9.6%) 1 (14.3%) /
 2nd degree relative / 14 (5.5%) 14 (5.6%) 0 (0.0%) /
Smoker or Ex-Smoker 358 (30.6%) 121 (33.8%) 117 (33.5%) 4 (44.4%) 0.49
Tumor localization 514 (0.4%) / / / 0.84
 Cecum/Appendix / 56 (10.9%) 56 (11.2%) 0 (0.0%) /
 Ascending colon / 37 (7.2%) 35 (7.0%) 2 (13.3%) /
 Right flexure / 15 (2.9%) 14 (2.8%) 1 (6.7%) /
 Transverse colon / 19 (3.7%) 18 (3.6%) 1 (6.7%) /
 Left flexure / 22 (4.3%) 21 (4.2%) 1 (6.7%) /
 Descending colon / 9 (1.75%) 9 (1.8%) 0 (0.0%) /
 Sigma / 107 (20.8%) 104 (20.8%) 3 (20.0%) /
 Rectum / 246 (47.9%) 239 (47.9%) 7 (46.7%) /
  ≥ 2 localizations / 3 (0.6%) 3 (0.6%) 0 (0.0%) /
TNM 509 (1.4%) / / / 0.75
 T1 / 9 (1.8%) 9 (1.8%) 0 (0.0%) /
 T2 / 27 (5.3%) 27 (5.5%) 0 (0.0%) /
 T3 / 372 (73.1%) 360 (72.9%) 12 (80.0%) /
 T4 / 101 (19.8%) 98 (19.8%) 3 (20.0%) /
TNM 503 (2.5%) / / / 0.39
 N0 / 149 (29.6%) 144 (29.5%) 5 (33.3%) /
 N1 / 215 (42.7%) 211 (43.2%) 4 (26.7%) /
 N2 / 139 (27.6%) 133 (27.3%) 6 (40.0%) /
Stage 512 (0.8%) / / / 0.81
 Stage II / 151 (29.5%) 147 (29.6%) 4 (26.7%) /
 Stage III / 361 (70.5%) 350 (70.4%) 11 (73.3%) /
Adjuvant chemotherapy 516 (0.0%) 339 (65.7%) 329 (65.7%) 10 (66.7%) 0.94
  1. Distribution overall and by total recurrence status. Continuous variables are summarized as medians [25th percentile (Q1) – 75th percentile (Q3)], whereas categorical variables are reported as absolute frequencies and percentages. *p-values for difference between non-VTE and VTE group are from Pearson’s chi-squared tests (categorical variables with expected cell counts ≥5), Fisher’s exact tests (categorical variables with expected cell counts <5), or Wilcoxon rank-sum tests (continuous variables)
  2. Abbreviations: KI – Karnofsky Index, TNM – Tumor Node Metastasis classification, BMI – Body mass index, CRC – Colorectal cancer