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Table 3 Proportion Enrolled on Trial by Diagnosis

From: Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

  Total < 2007 ≥ 2007 P Value*
N = 4608 N = 4596
 Leukemia 1199/2699 (44.4%) 547/1362 (40.2%) 652/1337 (48.8%)  
  Acute lymphoblastic leukemia 1043/2138 (48.8%) 484/1075 (45.0%) 559/1063 (52.6%) 0.0006
  Acute myeloid leukemia 138/395 (34.9%) 50/192 (26.0%) 88/203 (43.3%) 0.0005
  Other leukemias 18/166 (10.8%) 13/95 (13.7%) 5/71 (7.0%) 0.267
 Lymphoma 270/962 (28.1%) 167/504 (33.1%) 103/458 (22.5%)  
  Hodgkin lymphoma 130/400 (32.5%) 61/200 (30.5%) 69/200 (34.5%) 0.455
  Non-Hodgkin lymphoma excluding Burkitt’s lymphoma 90/340 (26.5%) 64/180 (35.6%) 26/160 (16.3%) <0.0001
  Burkitt’s lymphoma 37/162 (22.8%) 31/91 (34.1%) 6/71 (8.5%) 0.0002
  Other lymphomas 13/60 (21.7%) 11/33 (33.3%) 2/27 (7.4%) 0.035
 Solid Tumors 827/3187 (25.9%) 435/1556 (28.0%) 392/1631 (24.0%)  
  Ewing sarcoma 63/164 (38.4%) 39/82 (47.6%) 24/82 (29.3%) 0.025
  Hepatoblastoma 22/139 (15.8%) 15/70 (21.4%) 7/69 (10.1%) 0.112
  Neuroblastoma and ganglioneuroblastoma 237/734 (32.3%) 140/363 (38.6%) 97/371 (26.1%) 0.0004
  Osteosarcoma 78/207 (37.7%) 35/98 (35.7%) 43/109 (39.4%) 0.682
  Rhabdomyosarcoma 121/273 (44.3%) 68/135 (50.4%) 53/138 (38.4%) 0.062
  Wilms tumor 160/424 (37.7%) 66/204 (32.4%) 94/220 (42.7%) 0.036
  Other solid tumors 146/1246 (11.7%) 72/604 (11.9%) 74/642 (11.5%) 0.898
 Central Nervous System Tumors 237/2307 (10.3%) 134/1167 (11.5%) 103/1140 (9.0%)  
  Astrocytoma 52/982 (5.3%) 26/508 (5.1%) 26/474 (5.5%) 0.909
  Ependymoma 38/197 (19.3%) 24/93 (25.8%) 14/104 (13.5%) 0.044
  Medulloblastoma 36/172 (20.9%) 15/88 (17.0%) 21/84 (25.0%) 0.274
  Other central nervous system tumors 111/956 (11.6%) 69/478 (14.4%) 42/478 (8.8%) 0.009
  1. *P values by Chi square test