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Table 1 Results of univariate long-rank analysis of prognostic factors for overall survival and disease-free survival

From: CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma

Parameters No. of patients Overall survival Disease-free survival
No. of events P value No. of events P value
Age, years
  ≤ 60 54 31 0.452 36 0.757
  > 60 51 33   34  
Gender
 Male 58 39 0.392 38 0.538
 Female 47 25   32  
Gross pattern
 MF 62 33 0.004a 40 0.142
 MF + PI 42 31   29  
Tumor N
 Solitary 87 50 0.021a 54 0.003a
 Multiple 16 12   15  
Tumor size
  ≤ 5 cm 52 32 0.084 27 < 0.001a
  > 5 cm 46 29   38  
Margin
  ≤ 1 cm 66 45 0.025a 49 0.011a
  > 1 cm 28 15   17  
Necrosis
  ≤ 10% 77 45 0.134 49 0.104
  > 10% 28 19   21  
VI
 No 64 37 0.122 35 0.001a
 Yes 41 27   35  
NI
 No 67 35 < 0.001a 39 0.003a
 Yes 38 29   31  
H grade
 I 29 19 0.776 17 0.398
 II + III 76 45   53  
pT
 T1 34 16 0.008a 18 0.005a
 T2 - T4 67 47   50  
LN
 No 40 23 0.198 26 0.353
 Yes 12 8   9  
Stage
 I 30 14 0.006a 16 0.009a
  II + III + IV 71 49   52  
CUL4A
  < 50 71 42 0.245 42 0.011a
  ≥ 50 34 22   28  
  1. M mass-forming type, PI periductal infiltrating type, N number, VI vascular invasion, NI neural invasion, H histology, pT tumor stage, LN lymph node metastasis
  2. aStatistically significant