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Table 2 DNA copy number of BCL2 family genes in parental cell lines and venetoclax-resistant populations. Key changes are highlighted in bold

From: Potential mechanisms of resistance to venetoclax and strategies to circumvent it

  Cell Lines
Primary Sequence Name OCI-Ly1 parent OCI-Ly1 199R SC-1 parent SC-1 199R HBL1 parent HBL1 199R U2932 Parent U2932 199R RS4;11 parent RS4;11 199R HBL2 parent HBL2 199R Granta-519 parent Granta-519 199R
BCL2 0.46 0.46 6.00 7.79 3.01 3.19 14.86 7.08 2.05 1.97 6.07 1.34 5.99 5.61
BCL2L1 2.08 2.27 2.17 9.16 2.08 2.03 2.09 2.14 2.06 2.05 1.93 1.99 1.83 1.85
MCL1 2.07 3.21 2.18 5.12 2.11 2.04 9.99 11.25 2.16 2.10 2.99 1.96 2.39 2.40
BCL2A1 2.04 2.08 2.10 2.07 2.08 2.03 3.05 2.88 2.00 2.03 1.91 1.91 2.33 2.05
BCL2L2 2.06 2.15 2.11 2.10 2.08 2.05 2.08 2.10 2.18 2.14 1.95 1.99 1.30 1.29
BAX 2.09 2.22 2.18 2.00 2.17 2.04 3.12 2.92 2.17 2.18 2.06 1.99 2.48 2.43
BAK1 2.06 2.17 2.23 2.12 1.13 1.01 2.16 2.16 2.12 2.11 2.02 2.10 1.94 1.93
BID 2.07 2.23 2.30 2.18 2.21 2.08 2.18 2.05 2.24 2.20 2.04 2.11 1.98 2.13
BCL2L11 2.02 2.10 2.46 2.02 2.10 0.46 1.13 2.01 1.99 1.99 1.97 2.21 1.93 2.12
PMAIP1 1.99 1.55 3.07 2.26 3.12 3.15 18.25 9.50 2.05 1.97 3.76 1.26 6.22 5.61
BBC3 2.09 2.22 2.24 2.00 2.17 2.04 3.12 2.92 2.17 2.18 2.06 1.99 2.41 2.43
BAD 2.01 2.11 2.36 2.18 2.07 2.05 2.11 2.07 2.12 2.12 2.05 2.00 1.86 1.60