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Table 3 List of genes containing >1 amino acid change causing mutation and the significance of the mutation beyond background mutation rate (convoluted p-value <0.05)

From: Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

Gene (KEGG pathway)

Mutations

Samples affected

No. strains affected

p-value

Nkd1 (Wnt signalling pathway)

p.P84L|p.V47I

AB1|AB22

1 (BALB/c)

1.34E-04

Mmp8

p.L7P|p.F303 V

AB1|AB22

1 (BALB/c)

5.38E-04

Nckap5

p.P1182H, p.L1191 V, p.G768D

AB1|AB13|AE16

2 (BALB/c|C57BL/6)

9.96E-04

Dab1

p.F203C|p.L502 V

AB1

1 (BALB/c)

1.22E-03

Dsc1

p.K481 N|p.E519D

AB1|AB13

1 (BALB/c)

1.45E-03

Rftn1

p.V106G|p.W404C

AB1|AB13

1 (BALB/c)

2.43E-02

Ano4

p.N644 K|p.N406Y

AB22

1 (BALB/c)

2.07E-03

Dpp9

p.T763R|p.P403T

AB1

1 (BALB/c)

3.74E-03

Pabpc6

p.G402R|p.D45Y

AB1|AB22

1 (BALB/c)

3.29E-03

Hoxd3

p.Q7K|p.V388 M

AE17|AE19

1 (C57BL/6)

4.81E-03

Hc

p.V1332 M|p.I25M

AB22

1 (BALB/c)

3.51E-03

Dock10

p.V1546G|p.A2076V

AB1|AE17

2 (BALB/c|C57BL/6)

3.28E-03

Cacna2d2 (MAPK signalling pathway)

p.K857 M|p.R575Q

AB1|AC28

2 (BALB/c|CBA)

3.67E-03

Neurl4

p.V1163I|p.T832 K

AC29|BM163

2 (CBA|C57BL/6)

6.50E-03

Fat3

p.D2918G|p.D1300E

AB1

1 (BALB/c)

3.61E-02