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Fig. 1 | BMC Cancer

Fig. 1

From: Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

Fig. 1

Copy number variations in genes frequently altered in human MM tumours were identified in murine MM tumour cell lines. As an example, Cdkn2a loss is shown in sample AB22, Trp53 loss is shown in AC29 and Myc amplification is shown in AC28 (a). The mutation status was assessed for a group of genes selected based on frequent somatic alteration in human MM (See Additional file 3) (b). Scaled fold-change of the mRNA expression of each target, compared back to the strain matched control, as determined by qPCR, is shown as reduced (red) or increased (green) (c)

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