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Table 5 Clinicopathologic characteristics according to MSI status

From: The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients

  Patients with MSI status p-value
MSS/MSI-L MSI-H total
(N = 77) (N = 6) (N = 83)
Sex     0.482
 Male 44 (57.1%) 2 (33.3%) 46 (55.4%)  
 Female 33 (42.9%) 4 (66.7%) 37 (44.6%)  
Age     0.608
  < 50 year 13 (16.9%) 0 (0.0%) 13 (15.7%)  
  ≥ 50 year 64 (83.1%) 6 (100.0%) 70 (84.3%)  
Location     0.037
 Rt colon 18 (23.4%) 4 (66.7%) 22 (26.5%)  
 Lt colon 39 (50.6%) 1 (16.7%) 40 (48.2%)  
 Rectum 17 (22.1%) 0 (0.0%) 17 (20.5%)  
 Multiple 3 (3.9%) 1 (16.7%) 4 (4.8%)  
Stage     0.642
 StageI 14 (18.2%) 2 (33.3%) 16 (19.3%)  
 StageII 27 (35.1%) 2 (33.3%) 29 (34.9%)  
 StageIII 36 (46.8%) 2 (33.3%) 38 (45.8%)  
T stage     0.984
 T1 9 (11.7%) 1 (16.7%) 10 (12.0%)  
 T2 13 (16.9%) 1 (16.7%) 14 (16.9%)  
 T3 39 (50.6%) 3 (50.0%) 42 (50.6%)  
 T4 16 (20.8%) 1 (16.7%) 17 (20.5%)  
N stage     0.788
 N0 41 (53.2%) 4 (66.7%) 45 (54.2%)  
 N1 14 (18.2%) 1 (16.7%) 15 (18.1%)  
 N2 22 (28.6%) 1 (16.7%) 23 (27.7%)  
Lymphatic invasion     0.971
 Absent 46 (59.7%) 3 (50.0%) 49 (59.0%)  
 Present 31 (40.3%) 3 (50.0%) 34 (41.0%)  
Venous invasion     0.378
 Absent 58 (75.3%) 6 (100.0%) 64 (77.1%)  
 Present 19 (24.7%) 0 (0.0%) 19 (22.9%)  
Perineural invasion     0.248
 Absent 53 (68.8%) 6 (100.0%) 59 (71.1%)  
 Present 24 (31.2%) 0 (0.0%) 24 (28.9%)  
Differentiation     0.012
 Well 13 (17.8%) 0 (0.0%) 13 (16.9%)  
 Moderate 59 (80.8%) 3 (75.0%) 62 (80.5%)  
 Poor 1 (1.4%) 1 (25.0%) 2 (2.6%)  
Histology     <0.001
 Non-mucinous adenocarcinoma 72 (93.5%) 1 (16.7%) 73 (88.0%)  
 Mucinous adenocarcinoma 5 (6.5%) 5 (83.3%) 10 (12.0%)  
Recur     0.608
 Recur 64 (83.1%) 6 (100.0%) 70 (84.3%)  
 Non-recur 13 (16.9%) 0 (0.0%) 13 (15.7%)  
Expire     1
 Expire 71 (92.2%) 6 (100.0%) 77 (92.8%)  
 Non-Expire 6 (7.8%) 0 (0.0%) 6 (7.2%)  
BRAF status     0.326
 Wild type 76 (98.7%) 5 (83.3%) 81 (97.6%)  
 Mutation 1 (1.3%) 1 (16.7%) 2 (2.4%)  
KRAS status     0.102
 Wild type 44 (57.1%) 6 (100.0%) 50 (60.2%)  
 Mutation 33 (42.9%) 0 (0.0%) 33 (39.8%)