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Table 2 Univariate and multivariate analysis of prognostic factors in the development cohort (n = 260)

From: An objective nodal staging system for breast cancer patients undergoing neoadjuvant systemic treatment

  Univariate Multivariate
P HR 95% CI for HR P HR 95% CI for HR
Age 0.643 0.995 0.973 1.017     
Tumor size 0.027 1.094 1.010 1.184 0.176 1.059 0.975 1.151
Axillary LN (1 cm) 0.006 1.097 1.028 1.172 0.051 1.072 1.000 1.149
High HG 0.001 2.226 1.377 3.598 0.014 1.934 1.146 3.266
HRc negative 0.005 1.841 1.204 2.815     
HER2 positive 0.608 1.132 0.706 1.814     
Subtypea 0.072     0.354    
HRc+/HER2+ 0.493 0.765 0.357 1.642 0.228 0.617 0.282 1.352
HRc−/HER2+ 0.043 1.857 1.050 3.381 0.226 1.469 0.788 2.737
HRc−/HER2- 0.036 1.717 1.035 2.847 0.468 1.222 0.711 2.103
Ki67 ≥ 10% 0.322 1.240 0.810 1.898     
  1. P values are derived from univariate or multivariate Cox proportional hazard models
  2. HR hazard ratio; CI confidence interval; LN lymph node; HG histologic grade; HRc hormone receptor; HER2 human epidermal growth factor receptor 2
  3. aHRc+/HER2- cases were used as reference group