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Table 3 Primary reasons for treatment discontinuation – from chart review

From: Treatment patterns and real world clinical outcomes in ER+/HER2- post-menopausal metastatic breast cancer patients in the United States

Primary reason for treatment discontinuation

First line (N = 220a)

Second line (N = 236a)

Third line (N = 113a)

n, (%)

n, (%)

n, (%)

Disease progression

168 (76.4%)

169 (71.6%)

57 (50.4%)

Total completion of treatment

31 (14.1%)

30 (12.7%)

7 (6.2%)

Toxicities or side effects

14 (6.4%)

8 (3.4%)

7 (6.2%)

Patient choice (non-financial)

4 (1.8%)

8 (3.4%)

5 (4.4%)

Financial reasons

1 (0.5%)

1 (0.4%)

1 (0.9%)

Drug resistance

2 (0.9%)

0 (0.0%)

1 (0.9%)

Patient physical status

0 (0.0%)

2 (0.8%)

1 (0.9%)

Death related to mBC

0 (0.0%)

5 (2.1%)

3 (2.7%)

Death not related to mBC

0 (0.0%)

2 (0.8%)

1 (0.9%)

Treatment still ongoing

0 (0.0%)

11 (4.7%)

30 (26.5%)

  1. There were more agents than patients per line (e.g. 220 agents vs. 178 patients in first line) as physicians were asked to provide reasons of discontinuation for every single agent rather than for every therapy
  2. mBC metastatic breast cancer
  3. aNumber of agents