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Table 2 Time to disease progression and PFS by drug category and treatment line – from chart review

From: Treatment patterns and real world clinical outcomes in ER+/HER2- post-menopausal metastatic breast cancer patients in the United States

Variable

First-line treatment

n

# Censored obs.a

Median (months)

95% confidence interval

p-valueb

Lower limit

Upper limit

 

Time to disease progression on first-line therapy (months) from start of first-line therapy

Aromatase inhibitors

103

8

12.0

10.0

13.1

 

Chemotherapy

25

13

7.9

6.0

8.3

 

Other

50

8

11.9

7.0

17.3

0.3563

Progression- free survival on second line therapy (months) from start of second-line therapy

Aromatase inhibitors

103

16

7.4

5.7

8.4

 

Chemotherapy

25

8

7.3

5.1

11.2

 

Other

50

19

8.1

7.0

12.0

0.1047

Progression- free survival on third-line therapy (months) from start of third-line therapy

Aromatase inhibitors

55

23

8.0

3.4

12.0

 

Chemotherapy

11

6

9.0

1.4

NE

 

Other

20

7

5.2

4.0

14.1

0.9176

  1. PFS Progression-free survival; NE Not Estimable
  2. aCensored patients are patients who have not had an event of disease progression, either because they dropped out from the trial for reasons other than disease progression or because they had not progressed when data were cut-off. b log rank test