Table 4 IL-8 -251 T > A polymorphism and the risk of gastroduodenal diseases
Genotype | Disease group | Unadjusted OR (95% CI) by univariate analysis | p | Adjusted OR (95% CI) by multivariate analysis | p |
|---|---|---|---|---|---|
T/A (heterozygote) | Hp(+) NAG (n = 49) | 0.74 (0.45–1.22) | 0.2406 | 0.76 (0.46–1.29) | 0.3018 |
Hp(+) mild AG (n = 27) | 1.06 (0.55–2.05) | 0.8581 | 1.09 (0.55–2.16) | 0.8052 | |
Hp(+) severe AG (n = 37) | 1.94 (0.99–3.82) | 0.0549 | 2.06 (1.01–4.21) | 0.0471 | |
Hp(−) DU(n = 3) | 0.79 (0.15–4.02) | 0.7729 | 0.84 (0.16–4.36) | 0.8342 | |
Hp(+) DU (n = 73) | 0.71 (0.45–1.11) | 0.1297 | 0.80 (0.50–1.29) | 0.3616 | |
Hp(−) GC(n = 46) | 1.57 (0.87–2.84) | 0.1326 | 1.66 (0.89–3.07) | 0.1058 | |
Hp(+) GC (n = 122) | 1.65 (1.06–2.58) | 0.0257 | 1.71 (1.07–2.72) | 0.0252 | |
A/A (mutant) | Hp(+) NAG (n = 7) | 0.55 (0.21–1.43) | 0.2237 | 0.59 (0.21–1.59) | 0.2952 |
Hp(+) mild AG (n = 5) | 1.03 (0.34–3.14) | 0.9593 | 1.00 (0.31–3.17) | 0.9941 | |
Hp(+) severe AG (n = 9) | 2.47 (0.93–6.59) | 0.0710 | 2.42 (0.85–6.84) | 0.0966 | |
Hp(−) DU (n = 1) | 1.37 (0.13–14.03) | 0.7895 | 1.66 (0.16–17.71) | 0.6743 | |
Hp(+) DU (n = 14) | 0.71 (0.33–1.55) | 0.3905 | 0.72 (0.32–1.63) | 0.4289 | |
Hp(−) GC (n = 7) | 1.25 (0.46–3.40) | 0.6577 | 1.19 (0.43–3.34) | 0.7403 | |
Hp(+) GC (n = 27) | 1.92 (0.95–3.86) | 0.0683 | 1.94 (0.93–4.06) | 0.0744 | |
T/A + A/A (A carrier) | Hp(+) NAG (n = 56) | 0.71 (0.44–1.15) | 0.1669 | 0.73 (0.44–1.22) | 0.2282 |
Hp(+) mild AG (n = 32) | 1.06 (0.56–1.99) | 0.8651 | 1.07 (0.55–2.08) | 0.8336 | |
Hp(+) severe AG (n = 46) | 2.03 (1.05–3.90) | 0.0351 | 2.12 (1.06–4.25) | 0.0335 | |
Hp(−) DU (n = 4) | 0.88 (0.19–4.05) | 0.8703 | 0.96 (0.20–4.48) | 0.3066 | |
Hp(+) DU (n = 87) | 0.71 (0.46–1.09) | 0.1152 | 0.79 (0.50–1.24) | 0.3035 | |
Hp(−) GC (n = 53) | 1.52 (0.86–2.70) | 0.1524 | 1.58 (0.87–2.87) | 0.1346 | |
Hp(+) GC (n = 149) | 1.70 (1.11–2.60) | 0.0155 | 1.74 (1.11–2.74) | 0.0161 |