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Table 1 Characteristics of the study population (male cases and controls from Australia and Germany)

From: Calretinin as a blood-based biomarker for mesothelioma

Characteristics

Australia

 

Germany

 

Group 1

Group 2

Group 3

 

Mesothelioma

Controls

Mesothelioma

Controls

Mesothelioma

Controls

Total

83

88

80

75

36

72

Histological subtype

 Epithelioid

27 (32.5%)

 

48 (60.0%)

 

28 (77.8%)

 

 Sarcomatoid

28 (33.7%)

 

0

 

0

 

 Biphasic

28 (33.7%)

 

12 (15.0%)

 

4 (11.1%)

 

 Not specified

0

 

20 (25.0%)

 

4 (11.1%)

 

Pathologic changes in controls

 Plaques

 

88 (100%)

 

55 (73.3%)

 

0

 Asbestosis

 

0

 

0

 

44 (61.1%)

 Asbestosis and plaques

 

0

 

20 (26.7%)

 

28 (38.9%)

Year of blood drawing

2005

2006

2012

2012

2011

2010

 Median (range)

(1996–2011)

(2000–2010)

(2011–2013)

(2011–2013)

(2008–2014)

(2009–2014)

Age at blood drawing [years]

 Median (range)

70 (53–84)

69.5 (52–84)

70 (41–89)

72 (53–90)

70 (34–85)

71 (43–83)

Calretinin storage time [months]

 Median (IQR)

81.5 (42.9–111)

59.8 (32.8–75.7)

17.2 (7.4–23.2)

19.3 (8.8–28.3)

3.6 (1.9–7)

10.9 (3.7–19.5)

Mesothelin storage time [months] Median (IQR)

n.a.

n.a.

21.3 (11.5–27.4)

21.5 (11.1–30.4)

7.5 (4.8–15.1)

26.8 (19.1–31.9)

Calretinin [ng/mL]

 N < limit of detection

30 (36.1%)

61 (69.3%)

20 (25.0%)

73 (97.3%)

12 (33.3%)

62 (86.1%)

 Median (IQR)

0.79 (<0.28–1.70)

<0.19 (<0.09–0.63)

1.10 (<0.48–2.16)

<0.01 (<0.01- < 0.08)

1.01 (<0.33–1.74)

<0.20 (<0.08- < 0.34)

 P-valuea

0.0197

<0.0001

0.0009

Mesothelin [nmol/L]

 N < limit of detection

0

0

1 (1.25%)

14 (18.7%)

0

0

 Median (IQR)

2.65 (1.38–5.54)

0.77 (0.53–1.08)

4.06 (2.22–11.9)

1.02 (0.46–1.45)

2.01 (1.44–3.83)

1.03 (0.73–1.21)

 P-valueb

<0.0001

<0.0001

<0.0001

  1. Storage time, time between blood drawing and measurement of calretinin or mesothelin; n.a. not available, IQR interquartile range
  2. a P-values obtained from two sided Peto-Prentice test
  3. b P-values obtained from two sided Wilcoxon rank-sum test