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Table 2 Univariate and multivariate analyses of prognostic factors for overall survival and progression-free survival

From: Preoperative Prognostic Nutritional Index is a Significant Predictor of Survival with Bladder Cancer after Radical Cystectomy: a retrospective study

Variable

Univariate

Multivariate

P value

HR (95% CI)

P Value

Overall survival

   

 Age (>65 vs. ≤65)

<0.001

1.615 (1.116–2.337)

0.011

 Gender (male vs. female)

0.264

  

 Histology type (NUC vs. UC)

0.363

  

 Pathological grade (3 vs. 2)

<0.001

  

 pT (pT2 or greater vs. pT1)

<0.001

2.796 (1.700–4.598)

<0.001

 pN status (positive vs. negative)

<0.001

1.682 (1.141–2.480)

0.009

 Smoking history

0.937

  

 Hypertension

0.480

  

 Diabetes Mellitus

0.534

  

 Heart disease

0.018

  

 Cerebrovascular disease

0.032

  

 ASA grade (3&4 vs. 1&2)

<0.001

1.641 (1.113–2.418)

0.012

 Hypoalbuminemia

<0.001

  

 Anemia

<0.001

  

 Postoperative complications

0.003

1.607 (1.076–2.400)

0.020

 PNI (low vs. high)

<0.001

1.668 (1.147–2.425)

0.007

 PLR (high vs. low)

<0.001

  

 NLR (high vs. low)

<0.001

1.416 (1.094–2.016)

0.014

 LMR (low vs. high)

<0.001

  

Progression-free survival

   

 Age (>65 vs. ≤65)

<0.001

  

 Gender (male vs. female)

0.304

  

 Histology type (NUC vs. UC)

0.683

  

 Pathological grade (3 vs. 2)

<0.001

  

 pT (pT2 or greater vs. pT1)

<0.001

2.560 (1.677–3.906)

<0.001

 pN status (positive vs. negative)

<0.001

1.871 (1.306–2.680)

0.001

 Smoking history

0.952

  

 Hypertension

0.604

  

 Diabetes Mellitus

0.681

  

 Heart disease

0.012

  

 Cerebrovascular disease

0.033

  

 ASA grade (3&4 vs. 1&2)

<0.001

1.561 (1.086–2.243)

0.016

 Hypoalbuminemia

<0.001

  

 Anemia

<0.001

  

 Postoperative complications

0.004

  

 PNI (low vs. high)

<0.001

1.680 (1.092–2.005)

0.011

 PLR (high vs. low)

<0.001

  

 NLR (high vs. low)

<0.001

1.550 (1.140–2.388)

0.008

 LMR (low vs. high)

<0.001

  
  1. UC urothelial carcinoma, NUC non-urothelial carcinoma, ASA American Society of Anesthesiologists, PNI prognostic nutritional index, NLR neutrophil-lymphocyte ratio, PLR platelet-lymphocyte ratio, LMR lymphocyte-monocyte ratio
  2. Significant values are in bold