|Category/Parameter||Complete Response (CR)||Partial Response (PR)||Stable Disease (SD)||Progressive Disease (PD)|
|18F FDG PET SULpeak||Resolution of target lesion activity: activity less than mean liver activity & indistinguishable from background blood-pool levels. Disappearance of all other lesions to background blood-pool levels.||
≥30% reduction of target lesion SULpeak. Absolute decrease ≥0.8 SUL units.|
Measurement is commonly in same lesion as baseline but can be another lesion if this is now the most active lesion after treatment.
|Does not fulfil criteria for response or progression||>30% increase of target lesion SULpeak. New 18F FDG avid lesions.|
|DW-MRI ADC50–900||Resolution of DWI signal||Persistence of DWI signal; >30% increase in ADCmean||Does not fulfil criteria for response or progression||Persistence of DWI signal; >25% reduction in ADCmean|
|Resolution of enhancement||Persistence of enhancement; >40% decrease in SInorm||Does not fulfil criteria for response or progression||Persistence of enhancement; >40% increase in SInorm|