Table 3 PET/MRI response categorisation
Category/Parameter | Complete Response (CR) | Partial Response (PR) | Stable Disease (SD) | Progressive Disease (PD) |
|---|---|---|---|---|
18F FDG PET SULpeak | Resolution of target lesion activity: activity less than mean liver activity & indistinguishable from background blood-pool levels. Disappearance of all other lesions to background blood-pool levels. | ≥30% reduction of target lesion SULpeak. Absolute decrease ≥0.8 SUL units. Measurement is commonly in same lesion as baseline but can be another lesion if this is now the most active lesion after treatment. | Does not fulfil criteria for response or progression | >30% increase of target lesion SULpeak. New 18F FDG avid lesions. |
DW-MRI ADC50–900 | Resolution of DWI signal | Persistence of DWI signal; >30% increase in ADCmean | Does not fulfil criteria for response or progression | Persistence of DWI signal; >25% reduction in ADCmean |
DCE-MRI SInormalised | Resolution of enhancement | Persistence of enhancement; >40% decrease in SInorm | Does not fulfil criteria for response or progression | Persistence of enhancement; >40% increase in SInorm |