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Table 1 Clinicopathological features of 19 tongue squamous cell carcinomas and immunohistochemistry of pVHL

From: Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

Case No. Stage VHL LOHa Gradeb pVHLc
Normal Dysplasia Tumor (differentiation)
Well Moderate Poor
1 II P 1   A ++ ++  
2 II P 1    ++   
3 II P 1    ++   
4 II P 2    ++ ++  
5 II N 1   A ++   
6 IV N 1    ++   
7 IV N 1 ++   ++   
8 I N 1 ++ B ++   
9 II ni 1    ++   
10 III ni 1 ++ C ++   +
11 I ni 1   A ++   
12 I ni 1 ++   ++   
13 II ni 1   A ++ ++  
14 I ni 1    ++   
15 II ni 1   A ++   
16 II ni 2    ++ ++ +
17 IV ni 2   A   ++  
18 III ni 2   A   ++  
19 III ni 3      +
Total     4 9 16 6 3
  1. a LOH, loss of heterozygosity, determined by single nucleotide polymorphism of the VHL gene (10). P, positive; N, negative; ni, non-informative
  2. b Grade 1, well-differentiated; grade 2, moderately differentiated; grade 3, poorly differentiated
  3. c All FFPE specimens from 19 cases were examined for histological features and immunohistochemistry of pVHL. All specimens examined were positive for pVHL: ++, strongly positive; +, weakly positive; patterns A, B and C are classifications of dysplasia determined by immunohistochemistry of pVHL together with CK13 and CK17, as shown in Fig. 2b