Fig. 2

Immunohistochemical staining of pVHL, CK13, and CK17 in tongue epithelial dysplasia lesions. Immunohistochemical staining of epithelial dysplasia. Tissues were stained with hematoxylin and eosin (first column), and immunohistologically stained for pVHL (second column), CK13 (third column), and CK17 (fourth column): a–d, normal tongue epithelium; e–h, dysplastic epithelial lesions (pattern A); i–l, dysplastic epithelial lesions (pattern B); m–p, dysplastic epithelial lesions (pattern C). Bars indicate 25 μm. Schematic patterns of immunohistochemical staining are shown at the bottom. Pattern A, pVHL completely overlapped with CK17; pattern B, normal epithelial cells were positive for CK17 but negative for pVHL; pattern C, dysplastic cells were negative for CK17 but positive for pVHL