TY - JOUR AU - Hasegawa, Hisashi AU - Kusumi, Yoshiaki AU - Asakawa, Takeshi AU - Maeda, Miyoko AU - Oinuma, Toshinori AU - Furusaka, Tohru AU - Oshima, Takeshi AU - Esumi, Mariko PY - 2017 DA - 2017/05/26 TI - Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium JO - BMC Cancer SP - 381 VL - 17 IS - 1 AB - Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigated and remains largely unknown. We performed immunohistochemical staining of pVHL in tongue tissues and dysplasia, and examined the association with LOH and its clinical significance. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-017-3364-8 DO - 10.1186/s12885-017-3364-8 ID - Hasegawa2017 ER -