Table 1 Inclusion and exclusion criteria according to the SENOMAC study protocol

Inclusion criteria

Primary invasive breast cancer T1-T3^a

Preoperative ultrasound of the axilla performed

Macrometastasis in not more than two lymph nodes at sentinel node biopsy

Written informed consent

Age 18 years or older

Exclusion criteria

Palpable regional lymph node metastasis prior to surgery

Regional or distant metastases outside of the ipsilateral axilla

Pregnancy

Bilateral invasive breast cancer, if one side meets any exclusion criteria

Medical contraindication for radiotherapy or systemic treatment

Inability to absorb or understand the meaning of the study information; for example, through disability, inadequate language skills or dementia

Prior history of invasive breast cancer