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Table 1 Clinical characteristics of patients with brain metastasis of uterine cancer

From: A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer

  Study cohort Validation cohort
  No. (%) Uterine corpus cancer Uterine cervical cancer p-value No. (%) p-value
  81 48 33   43  
Median age (range) 59 years (26-84) 60.5 (26-84) 58 (33-80)   56 (29-80)  
  < 65 51 (63) 27 (56) 24 (73) 0.13 34 (79) 0.06
  ≥ 65 30 (37) 21 (44) 9 (27)   9 (21)  
Histology
 Adenocarcinoma   34 8    
 Squamous cell carcinoma    19    
 Carcinosarcoma   5     
 Small cell carcinoma    3    
 Others   7 2    
 NA   2 1    
Primary tumor status     0.79   
 Controlled 38 (47) 22 (46) 16 (48)    
 Uncontrolled 39 (48) 23 (48) 16 (48)    
 NA 4 3 1    
Extracranial metastasis     0.35   0.05
 Yes 59 (73) 36 (75) 23 (70)   25 (58)  
 No 17 (21) 8 (17) 9 (27)   9 (21)  
 NA 5 4 1   9  
Mean time to BM 25 months (−11-130) 25 (−5-130) 33 (−11-114) >0.05 28 (−6-126) >0.05
Number of BM     0.35   
 1 28 (35) 20 (42) 8 (24)   26 (60) 0.01
 2-4 30 (37) 15 (31) 15 (45)   14 (32)  
 5-9 12 (15) 8 (17) 4 (12)   2 (5)  
 ≥ 10 7 (9) 5 (10) 2 (6)   1 (2)  
 meningeal carcinomatosis 4 (5) 0 4 (12)   0  
Site of BM     0.16   0.19
 supratentorial only 45 (56) 31 (65) 14 (42)   30 (70)  
 infratentorial involvement 32 (40) 17 (35) 15 (45)   13 (30)  
Karnofsky performance status     0.66   0.2
 90-100% 9 (11) 3 (6) 6 (18)   10 (23)  
 70-80% 29 (36) 18 (38) 11 (33)   17 (40)  
  < 70% 38 (47) 24 (50) 14 (42)   13 (30)  
 NA 5 3 2   3  
Recursive Partitioning Analysis     0.02   
 Class I 4 (5) 0 4 (12)    
 Class II 34 (42) 21 (44) 13 (39)    
 Class III 38 (47) 24 (50) 14 (42)    
 NA 5 3 2    
  1. BM brain metastases
  2. P-value are calculated using the chi-square test
  3. Significant values are in bold font