Table 1 Clinical characteristics of patients with brain metastasis of uterine cancer
Study cohort | Validation cohort | |||||
|---|---|---|---|---|---|---|
No. (%) | Uterine corpus cancer | Uterine cervical cancer | p-value | No. (%) | p-value | |
81 | 48 | 33 | 43 | |||
Median age (range) | 59 years (26-84) | 60.5 (26-84) | 58 (33-80) | 56 (29-80) | ||
< 65 | 51 (63) | 27 (56) | 24 (73) | 0.13 | 34 (79) | 0.06 |
≥ 65 | 30 (37) | 21 (44) | 9 (27) | 9 (21) | ||
Histology | ||||||
Adenocarcinoma | 34 | 8 | ||||
Squamous cell carcinoma | 19 | |||||
Carcinosarcoma | 5 | |||||
Small cell carcinoma | 3 | |||||
Others | 7 | 2 | ||||
NA | 2 | 1 | ||||
Primary tumor status | 0.79 | |||||
Controlled | 38 (47) | 22 (46) | 16 (48) | |||
Uncontrolled | 39 (48) | 23 (48) | 16 (48) | |||
NA | 4 | 3 | 1 | |||
Extracranial metastasis | 0.35 | 0.05 | ||||
Yes | 59 (73) | 36 (75) | 23 (70) | 25 (58) | ||
No | 17 (21) | 8 (17) | 9 (27) | 9 (21) | ||
NA | 5 | 4 | 1 | 9 | ||
Mean time to BM | 25 months (−11-130) | 25 (−5-130) | 33 (−11-114) | >0.05 | 28 (−6-126) | >0.05 |
Number of BM | 0.35 | |||||
1 | 28 (35) | 20 (42) | 8 (24) | 26 (60) | 0.01 | |
2-4 | 30 (37) | 15 (31) | 15 (45) | 14 (32) | ||
5-9 | 12 (15) | 8 (17) | 4 (12) | 2 (5) | ||
≥ 10 | 7 (9) | 5 (10) | 2 (6) | 1 (2) | ||
meningeal carcinomatosis | 4 (5) | 0 | 4 (12) | 0 | ||
Site of BM | 0.16 | 0.19 | ||||
supratentorial only | 45 (56) | 31 (65) | 14 (42) | 30 (70) | ||
infratentorial involvement | 32 (40) | 17 (35) | 15 (45) | 13 (30) | ||
Karnofsky performance status | 0.66 | 0.2 | ||||
90-100% | 9 (11) | 3 (6) | 6 (18) | 10 (23) | ||
70-80% | 29 (36) | 18 (38) | 11 (33) | 17 (40) | ||
< 70% | 38 (47) | 24 (50) | 14 (42) | 13 (30) | ||
NA | 5 | 3 | 2 | 3 | ||
Recursive Partitioning Analysis | 0.02 | |||||
Class I | 4 (5) | 0 | 4 (12) | |||
Class II | 34 (42) | 21 (44) | 13 (39) | |||
Class III | 38 (47) | 24 (50) | 14 (42) | |||
NA | 5 | 3 | 2 | |||