Table 2 BPFS and PFS log rank and Cox regression tests in primary PCa analyzed by qRT-PCR

Age

0.165

0.379

 ≤ 55

15

5 (73.3)

3 (79.4)

 56-65

81

43 (25.7)

29 (50.1)

 66-75

138

58 (45.4)

34 (69.8)

 > 75

36

18 (48.6)

8 (59.2)

Gleason-sp

< 0.0001

0.001

< 0.0001

0.015

 2-6

109

35 (56.4)

1

17 (77.3)

1

 7

129

63 (29.8)

2.94 (1.64-5.26)

< 0.0001

43 (57.4)

3.03 (1.4-6.53)

0.005

 Greater than 7

32

25 (11.7)

1.93 (1.18-3.16)

0.008

14 (0)

1.57 (0.83-2.96)

0.163

PSA (ng/ml)

< 0.0001

0.011

0.09

 10 or less

155

57 (47.8)

1

35 (68.6)

 10-20

74

37 (39.2)

2.12 (1.29-3.48)

0.003

24 (53.6)

 Greater than 20

40

29 (24.4)

1.72 (1.03-2.88)

0.036

15 (57.1)

cT

< 0.0001

0.013

0.029

1

0.002

 cT2b or less

248

107 (43)

1

66 (63.1)

2.46 (1.38-4.4)

 cT3a or greater

21

16 (14.5)

1.72 (1.03-3.67)

8 (58.6)

pT

< 0.0001

NS

0.001

NS

 pT2 or less

135

43 (57.4)

25 (77.9)

 pT3 or greater

135

80 (23)

49 (48.4)

pN

< 0.0001

0.043

0.2

 pN0

236

104 (43)

1

64 (63.6)

 pN1 or greater

12

11 (8.3)

1.98 (1.02-3.84)

5 (50.9)

Margins

< 0.0001

0.001

< 0.0001

0.039

 Negative

137

40 (56)

1

24 (77)

1

 Positive

133

83 (21.4)

2.14 (1.39-3.32)

50 (41.6)

1.74 (1.02-2.95)

TMPRSS2-ERG

0.105

0.957

 Negative

92

49 (32.5)

26 (63.9)

 Positive

178

74 (45.2)

48 (61.6)

IGF-1R

0.046

NS

0.835

 Low

67

34 (45.3)

17 (70.3)

 High

203

89 (41.9)

57 (61.4)

INSR

0.987

0.632

 Low

66

29 (52.1)

17 (69.9)

 High

199

92 (38.3)

57 (59.5)

IGF-1

< 0.0001

0.015

0.002

NS

 Low

67

44 (18.2)

1

26 (41.5)

 High

202

78 (48)

0.60 (0.39-0.90)

47 (68.6)

IGFBP-3

0.717

0.943

 Low

67

31 (45.9)

17 (61.3)

 High

203

92 (39.5)

57 (62.9)