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Table 2 BPFS and PFS log rank and Cox regression tests in primary PCa analyzed by qRT-PCR

From: Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status

Total cases   Biochemical progression Clinical Progression
Parameter n Events
(% BPFS)
p-Univariate HR (95% CI) p-Multivariate Events
(% PFS)
p-Univariate HR (95% CI) p-Multivariate
Age    0.165     0.379   
 ≤ 55 15 5 (73.3)     3 (79.4)    
 56-65 81 43 (25.7)     29 (50.1)    
 66-75 138 58 (45.4)     34 (69.8)    
 > 75 36 18 (48.6)     8 (59.2)    
Gleason-sp    < 0.0001   0.001   < 0.0001   0.015
 2-6 109 35 (56.4)   1   17 (77.3)   1  
 7 129 63 (29.8)   2.94 (1.64-5.26) < 0.0001 43 (57.4)   3.03 (1.4-6.53) 0.005
 Greater than 7 32 25 (11.7)   1.93 (1.18-3.16) 0.008 14 (0)   1.57 (0.83-2.96) 0.163
PSA (ng/ml)    < 0.0001   0.011   0.09   
 10 or less 155 57 (47.8)   1   35 (68.6)    
 10-20 74 37 (39.2)   2.12 (1.29-3.48) 0.003 24 (53.6)    
 Greater than 20 40 29 (24.4)   1.72 (1.03-2.88) 0.036 15 (57.1)    
cT    < 0.0001   0.013   0.029 1 0.002
 cT2b or less 248 107 (43)   1   66 (63.1)   2.46 (1.38-4.4)  
 cT3a or greater 21 16 (14.5)   1.72 (1.03-3.67)   8 (58.6)    
pT    < 0.0001   NS   0.001   NS
 pT2 or less 135 43 (57.4)     25 (77.9)    
 pT3 or greater 135 80 (23)     49 (48.4)    
pN    < 0.0001   0.043   0.2   
 pN0 236 104 (43)   1   64 (63.6)    
 pN1 or greater 12 11 (8.3)   1.98 (1.02-3.84)   5 (50.9)    
Margins    < 0.0001   0.001   < 0.0001   0.039
 Negative 137 40 (56)   1   24 (77)   1  
 Positive 133 83 (21.4)   2.14 (1.39-3.32)   50 (41.6)   1.74 (1.02-2.95)  
TMPRSS2-ERG    0.105     0.957   
 Negative 92 49 (32.5)     26 (63.9)    
 Positive 178 74 (45.2)     48 (61.6)    
IGF-1R    0.046   NS   0.835   
 Low 67 34 (45.3)     17 (70.3)    
 High 203 89 (41.9)     57 (61.4)    
INSR    0.987     0.632   
 Low 66 29 (52.1)     17 (69.9)    
 High 199 92 (38.3)     57 (59.5)    
IGF-1    < 0.0001   0.015   0.002   NS
 Low 67 44 (18.2)   1   26 (41.5)    
 High 202 78 (48)   0.60 (0.39-0.90)   47 (68.6)    
IGFBP-3    0.717     0.943   
 Low 67 31 (45.9)     17 (61.3)    
 High 203 92 (39.5)     57 (62.9)    
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