Table 2 Worst grade of adverse events observed during chemotherapy at phase I dose
|  | LEVEL 1 n = 6 | LEVEL 2 n = 6 | ||||
|---|---|---|---|---|---|---|
Grade (NCI-CTC ver. 3.0) | ||||||
Toxicity | 1–2 | 3 | 4 | 1–2 | 3 | 4 |
Leukocytes | 5 | 1 | 0 | 5 | 1 | 0 |
Neutrophils | 4 | 2 | 0 | 3 | 2 | 1 |
Hemoglobin | 5 | 1 | 0 | 5 | 1 | 0 |
Platelets | 6 | 0 | 0 | 4 | 0 | 2* |
Fatigue | 6 | 0 | 0 | 6 | 0 | 0 |
Anorexia | 6 | 0 | 0 | 6 | 0 | 0 |
Nausea | 6 | 0 | 0 | 6 | 0 | 0 |
Vomiting | 6 | 0 | 0 | 6 | 0 | 0 |
Esophagitis | 0 | 0 | 0 | 0 | 0 | 0 |
Diarrhea | 6 | 0 | 0 | 6 | 0 | 0 |
Constipation | 6 | 0 | 0 | 6 | 0 | 0 |
Alopecia | 6 | 0 | 0 | 6 | 0 | 0 |
FN | 6 | 0 | 0 | 6 | 0 | 0 |
Pheumonitis | 6 | 0 | 0 | 6 | 0 | 0 |
Hypertension | 5 | 1* | 0 | 6 | 0 | 0 |
Glaucoma | 6 | 0 | 0 | 5 | 1* | 0 |