Table 3 Overview of the most relevant genes associated with metastasis during liver colonisation (FDRÂ <Â 5%)
Gene | Ensembl ID | Gene Symbol | Functional Gene Group | p-value | Mean intensity CMT-93 | Mean intensity liver metastases | logFC* | logFC^ | FDR |
|---|---|---|---|---|---|---|---|---|---|
Matrix metallopepti-dase 7 | ENSMUSG00000018623 | MMP7 | Extracellular Matrix Proteins | 1,7 × 10−180 | 0,02 | 72,56 | 8,97 | 11,69 | 4,9 × 10−178 |
Keratin 20 | ENSMUSG00000035775 | KRT20 | CRC-Related Genes | 2,9 × 10−174 | 0,81 | 51,99 | 5,8 | 6,12 | 7,7 × 10−172 |
Wnt inhibitory factor 1 | ENSMUSG00000020218 | WIF1 | Wnt Signalling (canonical) | 3,7 × 10−126 | 0,00 | 20,68 | 7,37 | 12,85 | 3,3 × 10−124 |
Matrix metallopepti-dase 9 | ENSMUSG00000017737 | MMP9 | Extracellular Matrix Proteins | 3,8 × 10−72 | 0,10 | 14,16 | 5,95 | 7,92 | 9 × 10−71 |
Chemokine (C-X-C motif) receptor 4 | ENSMUSG00000045382 | CXCR4 | Cell Growth and Proliferation Genes | 1,5 × 10−71 | 0,02 | 19,29 | 7,06 | 10,50 | 3,4 × 10−70 |
Matrix metallopepti-dase 2 | ENSMUSG00000031740 | MMP2 | Extracellular Matrix Proteins | 1,8 × 10−70 | 0,09 | 27,83 | 7,04 | 8,33 | 4,2 × 10−69 |
Eph receptor B2 | ENSMUSG00000028664 | EPHB2 | Cell Growth and Proliferation Genes | 4,8 × 10−59 | 1,06 | 10,86 | 3,2 | 3,65 | 8 × 10−58 |
Chemokine (C-X-C motif) receptor 2 | ENSMUSG00000026180 | CXCR2 | Cell Growth and Proliferation Genes | 1,1 10−40 | 0,04 | 7,53 | 5,51 | 7,75 | 9,7 × 10−40 |
Cadherin 11 | ENSMUSG00000031673 | CDH11 | Cell Adhesion Genes | 8,8 × 10−40 | 0,12 | 6,32 | 4,67 | 5,75 | 7,9 × 10−39 |
Axin2 | ENSMUSG00000000142 | AXIN2 | Wnt Signalling (canonical) | 2,2 × 10−39 | 20,31 | 72,10 | 1,82 | 1,87 | 2 × 10−38 |
Integrin beta 3 | ENSMUSG00000020689 | ITGB3 | Cell Adhesion Genes | 1,6 × 10−33 | 5,54 | 25,48 | 2,17 | 2,35 | 1,2 × 10−32 |
Matrix metallopeptidase 13 | ENSMUSG00000050578 | MMP13 | Extracellular Matrix Proteins | 8,1 × 10−29 | 0,22 | 7,45 | 4,43 | 5,20 | 4,8 × 10−28 |
Glycoprotein (transmembrane) nmb | ENSMUSG00000029816 | GPNMB | Cell Adhesion Genes | 3,9 × 10−27 | 0,21 | 14,50 | 5,45 | 6,25 | 2,1 × 10−26 |
Snail family zinc finger 1 | ENSMUSG00000042821 | SNAI1 | EMT Transition | 2,9 × 10−26 | 0,12 | 3,05 | 3,62 | 4,66 | 1,5 × 10−25 |
Plasminogen activator, urokinase receptor | ENSMUSG00000046223 | PLAUR | Cell Growth and Proliferation Genes | 8,9 × 10−20 | 191,38 | 71,50 | −1,42 | −1,28 | 3,6 × 10−19 |
Matrix metallopeptidase 3 | ENSMUSG00000043613 | MMP3 | Extracellular Matrix Proteins | 3,7 × 10−17 | 0,05 | 2,70 | 3,95 | 5,74 | 1,3 × 10−16 |
Integrin alpha 6 | ENSMUSG00000027111 | ITGA6 | Cell Adhesion Genes | 5 × 10−17 | 12,03 | 31,23 | 1,36 | 1,32 | 1,8 × 10−16 |
Matrix metallopeptidase 10 | ENSMUSG00000047562 | MMP10 | Extracellular Matrix Proteins | 7,6 × 10−17 | 0,06 | 2,68 | 3,83 | 5,37 | 2,7 × 10−16 |
Somatostatin receptor 2 | ENSMUSG00000047904 | SSTR2 | Cell Growth and Proliferation Genes | 5,7 × 10−15 | 0,22 | 1,57 | 2,19 | 3,17 | 1,8 × 10−14 |
Jun proto-oncogene | ENSMUSG00000052684 | JUN | Transcription Factors and Regulators | 7,8 × 10−13 | 22,13 | 44,89 | 1,01 | 1,16 | 2,3 × 10−12 |
Frizzled homolog 2 (Drosophila) | ENSMUSG00000050288 | FZD2 | Wnt Signalling (canonical) | 1,1 × 10−12 | 6,88 | 2,16 | -1,7 | -1,54 | 3 × 10−12 |
Chemokine (C-C motif) ligand 7 | ENSMUSG00000035373 | CCL7 | Cell Growth and Proliferation Genes | 2,4 × 10−12 | 0,98 | 9,98 | 3,18 | 3,47 | 6,9 × 10−12 |
Nuclear receptor subfamily 4, group A, member 3 | ENSMUSG00000028341 | NR4A3 | Transcription Factors and Regulators | 3,5 × 10−12 | 0,16 | 1,22 | 2,1 | 3,31 | 1 × 10−11 |
RAR-related orphan receptor beta | ENSMUSG00000036192 | RORB | Cell Growth and Proliferation Genes | 2,6 × 10−11 | 2,57 | 0,70 | -1,94 | -1,68 | 7 × 10−11 |
Cyclin-dependent kinase inhibitor 2A | ENSMUSG00000044303 | CDKN2A | Transcription Factors and Regulators | 1,9 × 10−8 | 179,73 | 91,40 | −0,98 | −0,84 | 4,4 × 10−8 |
Matrix metallopeptidase 11 | ENSMUSG00000000901 | MMP11 | Extracellular Matrix Proteins | 6,6 × 10−7 | 12,30 | 5,36 | −1,21 | −1,19 | 1,4 × 10−6 |
Ets variant 4 | ENSMUSG00000017724 | ETV4 | Transcription Factors and Regulators | 9,5 × 10−7 | 21,60 | 10,13 | −1,1 | −0,93 | 1,9 × 10−6 |
Lymphoid enhancer binding factor 1 | ENSMUSG00000027985 | LEF1 | EMT Transition | 5,3 × 10−5 | 0,37 | 1,19 | 1,26 | 1,69 | 9,3 × 10−5 |
Caspase 3 | ENSMUSG00000031628 | CASP3 | Apoptosis Genes | 0,00027 | 48,58 | 29,55 | −0,72 | −0,57 | 0,00045 |
Fibronectin 1 | ENSMUSG00000026193 | FN1 | EMT Transition | 0,00085 | 1051,50 | 805,60 | −0,38 | −0,74 | 0,00134 |
B cell CLL/lymphoma 9 | ENSMUSG00000038256 | BCL9 | Wnt Signalling (canonical) | 0,00222 | 15,50 | 19,20 | 0,3 | 0,42 | 0,00336 |
Dickkopf homolog 2 (Xenopus laevis) | ENSMUSG00000028031 | DKK2 | Wnt Signalling (canonical) | 0,02671 | 9,31 | 6,03 | −0,65 | −0,50 | 0,03566 |