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Table 2 Patients’ characteristics and treatment

From: Oligometastases from prostate cancer: local treatment with stereotactic body radiotherapy (SBRT)

Patient

Gleason-Score

Concomitant ADT

Time between occurrence of metastasis and first diagnosis (years)

Tumor site

RT dose (Gy)

Prescribed dose in percentage

EQD2 (Gy) α/β = 2; α/β = 3

RT technique

Time between progress and end of RT (months)

PSA before RT (ng/ml)

PSA nadir (ng/ml)

PSA in progress (ng/ml)

1

8

No

3.1

Lumbar vertebra 2

5 × 6 (PTV), 5 × 8 (SIB)

Median

100; 88

VMAT

25.3

2.3

0.1

7.0

  

No

3.1

8th rib right

5 × 6.5

60%

173; 150

3D

 

2.3

0.1

7.0

2

8

Yes

2.8

Scapula left

5 × 6 PTV (GTV + asym. Safety margin) 5 × 8 SIB (GTV + 5 mm)

30Gy-isodose encloses 95% of PTV, SIB 95%

109; 96

VMAT

9.3

1.9

3.3 (x)

160

3

7

No

2.4

Pubic bone

5 × 6 PTV (GTV + 2 cm + 5 mm) 5 × 8 SIB (GTV + 5 mm) adapted to the bone margin

30Gy-isodose encloses 85% of PTV, SIB median

100; 88

VMAT

10.5

0.4

0.3

0.5

  

No

3.4

Iliac bone

5 × 6 PTV (GTV + 2 cm + 5 mm) 5 × 8 SIB (GTV + 5 mm) adapted to the bone margin

30Gy-isodose encloses PTV, SIB median

100; 88

VMAT

12.5

0.5

0.05

(y)

4

8

No

5.3

Cervical vertebra 5

5 × 5 (whole vertebra without spinal canal) 5 × 8 (SIB)

95%

109; 96

VMAT +3D

1.1

2.9

4.3 (x)

6.2

5

8

No

0.3

Thoracic vertebra 9, transverse process left

5 × 5 (whole vertebra without spinal canal) 5 × 8 SIB (GTV)

30Gy-isodose encloses 70% of PTV, SIB median

100; 88

Tomotherapy

3.4

11.7

6.8

12

6

7

No

4.3

Lumbar vetrebra 4

5 × 6 (whole vertebra without spinal canal) 5 × 8 SIB (GTV + 5 mm)

30Gy-isodose encloses 60% of PTV, SIB median

100; 88

VMAT

6.2

0.9

0.9

10.7

7

9

No

4.6

10th rib right

5 × 5.4

60%

124; 108

3D

6.9

4.7

3.9

6.9

  

No

4.6

Iliac bone left

5 × 6 PTV (GTV + asym. Safety margin) 5 × 8 SIB (GTV)

30Gy-isodose encloses 95% of PTV, 40 Gy-isodose encloses SIB

 

3D

6.9

4.7

3.9

6.9

8

7

Yes

6.0

Pubis bone right

5 × 7

60%

200; 171

3D

6.6

2.2

1.8

2.4

9

9

No

5.3

2nd rib left

5 × 6

60%

150; 130

3D

N

1.2

0.0

(y)

10

6

No

10.4

5th rib left

5 × 6

60%

150; 130

3D

1.7

2.0

(z)

4.3

11

7

No

4.3

Thoracic vertebra 7

5 × 5 (whole vertebra without spinal canal) 5 × 8 (SIB)

Median

100; 88

TomoTherapy

28.4

2.7

0.17

0.8

12

9

No

0.9

Pubic bone right

5 × 6

60%

150; 130

VMAT

6.9

0.9

1.3 (x)

4.1

13

7

Yes

0.0

Lumbar vertebra 4

5 × 5 (whole vertebra without spinal canal) 5 × 7 (SIB)

95%

86, 77

VMAT

N

15.0 (iPSA)

n.a. (w)

n.a.

14

G3

No

17.2

4th rib left

5 × 7

60%

 

3D

12.1

1.5

0.3

3.4

15

9

No

9.1

Acetabulum left

5 × 6 (Acetabulum dorsal) 5 × 7 (GTV + asym. Safety margin)

95%

86; 77

VMAT

23.1

3.9

0.3

0.9

  

No

11.2

Thoracic vertebra 4, Spinous process

5 × 5 (Spinous process) 5 × 7 (GTV)

95%

86; 77

VMAT

3.6

0.9

0.19

0.8

  

No

12.0

Thoracic vertebra 5

5 × 7 Gy, GTV + 2 mm (due to pre-RT)

median

79; 70

3D

2.1

0.8

(z)

n.a.

  1. (x) = shows no nadir, PSA level increases directly after RT
  2. (y) = no progress until now
  3. (z) = ADT was started 4 weeks after RT, so nadir was not available
  4. (w) = patient started concomitant hormone-chemotherapy, surgery of the primary follows