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Table 2 Patients’ characteristics and treatment

From: Oligometastases from prostate cancer: local treatment with stereotactic body radiotherapy (SBRT)

Patient Gleason-Score Concomitant ADT Time between occurrence of metastasis and first diagnosis (years) Tumor site RT dose (Gy) Prescribed dose in percentage EQD2 (Gy) α/β = 2; α/β = 3 RT technique Time between progress and end of RT (months) PSA before RT (ng/ml) PSA nadir (ng/ml) PSA in progress (ng/ml)
1 8 No 3.1 Lumbar vertebra 2 5 × 6 (PTV), 5 × 8 (SIB) Median 100; 88 VMAT 25.3 2.3 0.1 7.0
   No 3.1 8th rib right 5 × 6.5 60% 173; 150 3D   2.3 0.1 7.0
2 8 Yes 2.8 Scapula left 5 × 6 PTV (GTV + asym. Safety margin) 5 × 8 SIB (GTV + 5 mm) 30Gy-isodose encloses 95% of PTV, SIB 95% 109; 96 VMAT 9.3 1.9 3.3 (x) 160
3 7 No 2.4 Pubic bone 5 × 6 PTV (GTV + 2 cm + 5 mm) 5 × 8 SIB (GTV + 5 mm) adapted to the bone margin 30Gy-isodose encloses 85% of PTV, SIB median 100; 88 VMAT 10.5 0.4 0.3 0.5
   No 3.4 Iliac bone 5 × 6 PTV (GTV + 2 cm + 5 mm) 5 × 8 SIB (GTV + 5 mm) adapted to the bone margin 30Gy-isodose encloses PTV, SIB median 100; 88 VMAT 12.5 0.5 0.05 (y)
4 8 No 5.3 Cervical vertebra 5 5 × 5 (whole vertebra without spinal canal) 5 × 8 (SIB) 95% 109; 96 VMAT +3D 1.1 2.9 4.3 (x) 6.2
5 8 No 0.3 Thoracic vertebra 9, transverse process left 5 × 5 (whole vertebra without spinal canal) 5 × 8 SIB (GTV) 30Gy-isodose encloses 70% of PTV, SIB median 100; 88 Tomotherapy 3.4 11.7 6.8 12
6 7 No 4.3 Lumbar vetrebra 4 5 × 6 (whole vertebra without spinal canal) 5 × 8 SIB (GTV + 5 mm) 30Gy-isodose encloses 60% of PTV, SIB median 100; 88 VMAT 6.2 0.9 0.9 10.7
7 9 No 4.6 10th rib right 5 × 5.4 60% 124; 108 3D 6.9 4.7 3.9 6.9
   No 4.6 Iliac bone left 5 × 6 PTV (GTV + asym. Safety margin) 5 × 8 SIB (GTV) 30Gy-isodose encloses 95% of PTV, 40 Gy-isodose encloses SIB   3D 6.9 4.7 3.9 6.9
8 7 Yes 6.0 Pubis bone right 5 × 7 60% 200; 171 3D 6.6 2.2 1.8 2.4
9 9 No 5.3 2nd rib left 5 × 6 60% 150; 130 3D N 1.2 0.0 (y)
10 6 No 10.4 5th rib left 5 × 6 60% 150; 130 3D 1.7 2.0 (z) 4.3
11 7 No 4.3 Thoracic vertebra 7 5 × 5 (whole vertebra without spinal canal) 5 × 8 (SIB) Median 100; 88 TomoTherapy 28.4 2.7 0.17 0.8
12 9 No 0.9 Pubic bone right 5 × 6 60% 150; 130 VMAT 6.9 0.9 1.3 (x) 4.1
13 7 Yes 0.0 Lumbar vertebra 4 5 × 5 (whole vertebra without spinal canal) 5 × 7 (SIB) 95% 86, 77 VMAT N 15.0 (iPSA) n.a. (w) n.a.
14 G3 No 17.2 4th rib left 5 × 7 60%   3D 12.1 1.5 0.3 3.4
15 9 No 9.1 Acetabulum left 5 × 6 (Acetabulum dorsal) 5 × 7 (GTV + asym. Safety margin) 95% 86; 77 VMAT 23.1 3.9 0.3 0.9
   No 11.2 Thoracic vertebra 4, Spinous process 5 × 5 (Spinous process) 5 × 7 (GTV) 95% 86; 77 VMAT 3.6 0.9 0.19 0.8
   No 12.0 Thoracic vertebra 5 5 × 7 Gy, GTV + 2 mm (due to pre-RT) median 79; 70 3D 2.1 0.8 (z) n.a.
  1. (x) = shows no nadir, PSA level increases directly after RT
  2. (y) = no progress until now
  3. (z) = ADT was started 4 weeks after RT, so nadir was not available
  4. (w) = patient started concomitant hormone-chemotherapy, surgery of the primary follows