Table 2 Main characteristics and results of the studies evaluating lymphovascular invasion prognostic values

Arnaout-Alkarain, 2007, Canada [26]

55.5^mean (26.6–89.7)

D2–40 (0.1 μg/ml)

91.2^median

82/303 (27.1)

DFS (+), OS (+)

El-Gohary, 2008, USA [30]

64^mean (27–89)

D2–40 (1:50)

DFS 30.6^mean (12–58) OS 55.2^mean (7–84)

18/48 (37.5)

DFS (+), OS (+)

Gudlaugsson, 2011, Norway [13]

not given

D2–40 (1:200)

117^median (12–192)

51/240 (21.3)

DFS (−), OS (+)

Ito, 2007, Japan [27]

52.1^mean (27–80)

D2–40 (1:200)

47.5^mean

16/69 (23.2)

DFS (+), OS (−)

Mohammed, 2011, UK [31]

54^median (18–75)

D2–40 (1:100)

107.12^mean (1–311)

213/1005 (21.2)

DFS (+), OS (+)

Mohammed, 2014, UK [14]

52^median (18–72)

D2–40 (1:100)

117^mean (4–246)

262/557 (47.0)

DFS (+), OS (+)

Schoppmann, 2004, Austria [25]

57.6^median

podoplanin (1:200)

268.4^mean (8–510)

105/374 (28.1)

DFS (+), OS (+)

Tezuka, 2007, Japan [28]

55.9^median (31–84)

D2–40 (NG)

69^mean

55/132 (41.7)

DFS (+), OS (−)

van der Schaft, 2007, Netherlands [18]

61.4^mean

Podoplanin (NG)

80.5^mean

not given

DFS (+), OS (−)

Yamauchi, 2007, Japan [29]

53^mean (28–84)

D2–40 (1:200)

101^median

not given

DFS (+), OS (+)

Zhang, 2008, China [20]

49^median (30–77)

D2–40 (1:100)

68^median (28–83)

25/70 (35.7)

DFS (+), OS (−)