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Table 2 Estimated IC50 mean values for parent OVA-BS4 and OVA-BS4 spheroids

From: MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis

Drugs parent OVA-BS4 OVA-BS4 spheroids Fold change P value
Cisplatin (μM) 5.72 ± 0.90 85.23 ± 60.10 14.9 <0.0001
Paclitaxel (nM) 62.09 ± 16.19 600.00a >10 <0.0001
Etoposide (μM) 1.57 ± 0.18 120.00a >76 <0.0001
Doxorubicin (μM) 0.22 ± 0.10 3.11 ± 0.29 14.1 <0.0001
PS341 (nM) 29.51 ± 11.70 530.83 ± 109.33 18.0 <0.0001
Trabectedin (nM) 5.05 ± 1.44 8.75 ± 0.35 1.7 0.002
  1. aThe value corresponds to the maximum dose tested, even if not sufficient to kill the 50% of cells