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Table 2 Estimated IC50 mean values for parent OVA-BS4 and OVA-BS4 spheroids

From: MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis

Drugs

parent OVA-BS4

OVA-BS4 spheroids

Fold change

P value

Cisplatin (ÎĽM)

5.72 ± 0.90

85.23 ± 60.10

14.9

<0.0001

Paclitaxel (nM)

62.09 ± 16.19

600.00a

>10

<0.0001

Etoposide (ÎĽM)

1.57 ± 0.18

120.00a

>76

<0.0001

Doxorubicin (ÎĽM)

0.22 ± 0.10

3.11 ± 0.29

14.1

<0.0001

PS341 (nM)

29.51 ± 11.70

530.83 ± 109.33

18.0

<0.0001

Trabectedin (nM)

5.05 ± 1.44

8.75 ± 0.35

1.7

0.002

  1. aThe value corresponds to the maximum dose tested, even if not sufficient to kill the 50% of cells
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BMC Cancer

ISSN: 1471-2407

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