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Table 3 Multivariate Cox regression model adjusted for possible predictors estimating cancer-specific and overall survival in 244 patients treated with cyto-reductive nephrectomy for metastatic renal cell carcinoma

From: Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy

 

Cancer-specific survival

Overall survival

HR

95% CI of HR

p value

HR

95% CI of HR

p value

Age

1.002

0.983–1.021

0.865

1.003

0.986–1.021

0.713

BMI (kg/m 2)

Reference (< 20)

Reference (< 20)

 20–25

0.792

0.459–1.369

0.404

0.805

0.485–1.336

0.402

  ≥ 25

0.443

0.202–0.924

0.030

0.466

0.232–0.936

0.032

Albumin (g/dL)

Reference (< 3.5)

Reference (< 3.5)

 3.5–4.3

0.776

0.440–1.370

0.382

0.716

0.426–1.204

0.208

  ≥ 4.3

0.784

0.399–1.544

0.482

0.713

0.383–1.328

0.287

Heng’s criteria

Reference (Low risk)

Reference (Low risk)

 Intermediate risk

1.095

0.623–1.926

0.752

1.033

0.619–1.725

0.902

 High risk

1.185

0.550–2.553

0.664

1.132

0.565–2.270

0.727

 Cholesterol level (cat.)

2.162

1.221–3.829

0.008

2.013

1.206–3.361

0.007

Age

1.002

0.983–1.021

0.830

1.003

0.986–1.021

0.701

BMI (kg/m 2)

Reference (< 20)

Reference (< 20)

 20–25

0.827

0.479–1.430

0.497

0.857

0.517–1.420

0.549

  ≥ 25

0.462

0.214–0.997

0.049

0.503

0.249–1.017

0.056

Albumin (g/dL)

Reference (< 3.5)

Reference (< 3.5)

 3.5–4.3

0.882

0.498–1.561

0.665

0.789

0.468–1.327

0.371

  ≥ 4.3

0.892

0.437–1.821

0.753

0.769

0.401–1.473

0.428

Heng’s criteria

Reference (Low risk)

Reference (Low risk)

 Intermediate

1.060

0.601–1.870

0.840

1.024

0.613–1.712

0.927

 High risk

1.235

0.576–2.649

0.588

1.193

0.596–2.389

0.618

 Cholesterol level (con.)

0.993

0.987–0.999

0.032

0.995

0.989–1.000

0.063

  1. HR hazard ratio, CI confidence interval, BMI body mass index, con. Continuous variable, cat. Categorical variable