Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation

Table 4 Results of the gene-based association test from VEGAS (only genes with P _Gene < 0.05 or best SNP P _{per allele} < 0.05 are shown)

Chr	Gene	Start	Stop	Number of tested SNPs	Number of simulations	Test	P _Gene	Best SNP	P _{per allele}
10	MGMT	131,215,453	131,615,783	4	1e + 05	13.93	0.008	rs2296675	0.0006
13	ERCC5	103,448,190	103,578,351	2	1e + 06	9.39	0.01	rs1047768	0.02
20	PCNA	5,045,598	5,157,268	3	1e + 05	9.30	0.05	rs17349	0.03
7	PMS2	5,962,869	6,098,737	4	1000	8.70	0.09	rs3735295	0.04
1	PARP1	226,498,391	226,645,801	5	1000	11.05	0.11	rs747659	0.03
3	OGG1	9,741,627	9,858,353	2	1000	4.30	0.13	rs125701	0.05
2	XRCC5	216,924,019	217,121,016	4	1000	7.79	0.13	rs1051685	0.008

Chr chromosome, Start coordinate of the 5′ end of the gene on the chromosome, Stop coordinate of the 3′ end of the gene on the chromosome.

ISSN: 1471-2407