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Table 2 Distribution of the 43 DNA repair genes per DNA repair module as described in the ACSN. The number of tested SNPs per group of genes is indicated in italic and in brackets

From: Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation

 

NER

BER

MMR

SSA

NHEJ

MMEJ

HR

FANCONI

DR

TLS

NER

14 [30]

         

BER

8 [19]

17 [47]

        

MMR

3 [9]

6 [21]

10 [47]

       

SSA

1 [2]

1 [9]

2 [13]

4 [16]

      

NHEJ

-

1 [5]

-

-

4 [13]

     

MMEJ

5 [8]

3 [4]

2 [2]

1 [2]

-

7 [13]

    

HR

-

2 [10]

1 [1]

1 [1]

1 [5]

2 [5]

13 [47]

   

FANCONI

2 [4]

-

-

1 [2]

-

2 [4]

4 [21]

7 [34]

  

DR

-

-

-

-

-

-

-

-

1 [4]

 

TLS

1 [3]

1 [3]

1 [3]

-

-

-

2 [9]

3 [18]

-

4 [21]

  1. NER nucleotide excision repair, BER base excision repair, MMR mismatch repair, SSA Single strand annealing, NHEJ non-homologous end joining, MMEJ microhomology-mediated end joining, HR homologous recombination, FANCONI Fanconi pathway, DR Direct repair, TLS translesion synthesis
  2. The 43 tested genes per DNA repair modules, with number of tested SNPs per gene indicated in brackets, are the following (some genes act in several modules): NER: ERCC1 [2], ERCC2 [2], ERCC3 [2], ERCC4 [2], ERCC5 [2], ERCC6 [2], LIG1 [5], LIG3 [1], PCNA [3], POLD1 [1], RAD23B [3], XPA [1], XPC [2], XRCC1 [2]; BER: APEX1 [1], ERCC5 [2], LIG1 [5], LIG3 [1], MBD4 [1], MLH1 [2], MSH2 [9], MSH6 [1], OGG1 [2], PARP1 [5], PCNA [3], POLB [2], POLD1 [1], RAD23B [3], WRN [5], XPC [2], XRCC1 [2]; MMR: EXO1 [1], LIG1 [5], MLH1 [2], MSH2 [9], MSH3 [4], MSH6 [1], PCNA [3], PMS1 [18], PMS2 [3], POLD1 [1]; SSA: ERCC1 [2], MSH2 [9], MSH3 [4], RAD52 [1]; NHEJ: LIG4 [1], PARP1 [5], XRCC4 [3], XRCC5 [4]; MMEJ: ERCC1 [2], ERCC4 [2], EXO1 [1], LIG3 [1], NBN [4], POLD1 [1], XRCC1 [2]; HR: BARD1 [1], BLM [4], BRCA1 [7], BRCA2 [5], BRIP1 [5], EXO1 [1], NBN [4], PARP1 [5], RAD51 [7], RAD52 [1], RAD54L [1], WRN [5], XRCC3 [1]; FANCONI: BLM [4], BRCA1 [7], BRCA2 [5], BRIP1 [5], ERCC1 [2], ERCC4 [2], FANCA [9]; DR: MGMT [4]; TLS: BLM [4], BRIP1 [5], FANCA [9], PCNA [3]
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BMC Cancer

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