| |
NER
|
BER
|
MMR
|
SSA
|
NHEJ
|
MMEJ
|
HR
|
FANCONI
|
DR
|
TLS
|
|---|
|
NER
|
14 [30]
| | | | | | | | | |
|
BER
|
8 [19]
|
17 [47]
| | | | | | | | |
|
MMR
|
3 [9]
|
6 [21]
|
10 [47]
| | | | | | | |
|
SSA
|
1 [2]
|
1 [9]
|
2 [13]
|
4 [16]
| | | | | | |
|
NHEJ
|
-
|
1 [5]
|
-
|
-
|
4 [13]
| | | | | |
|
MMEJ
|
5 [8]
|
3 [4]
|
2 [2]
|
1 [2]
|
-
|
7 [13]
| | | | |
|
HR
|
-
|
2 [10]
|
1 [1]
|
1 [1]
|
1 [5]
|
2 [5]
|
13 [47]
| | | |
|
FANCONI
|
2 [4]
|
-
|
-
|
1 [2]
|
-
|
2 [4]
|
4 [21]
|
7 [34]
| | |
|
DR
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
1 [4]
| |
|
TLS
|
1 [3]
|
1 [3]
|
1 [3]
|
-
|
-
|
-
|
2 [9]
|
3 [18]
|
-
|
4 [21]
|
-
NER nucleotide excision repair, BER base excision repair, MMR mismatch repair, SSA Single strand annealing, NHEJ non-homologous end joining, MMEJ microhomology-mediated end joining, HR homologous recombination, FANCONI Fanconi pathway, DR Direct repair, TLS translesion synthesis
- The 43 tested genes per DNA repair modules, with number of tested SNPs per gene indicated in brackets, are the following (some genes act in several modules): NER: ERCC1 [2], ERCC2 [2], ERCC3 [2], ERCC4 [2], ERCC5 [2], ERCC6 [2], LIG1 [5], LIG3 [1], PCNA [3], POLD1 [1], RAD23B [3], XPA [1], XPC [2], XRCC1 [2]; BER: APEX1 [1], ERCC5 [2], LIG1 [5], LIG3 [1], MBD4 [1], MLH1 [2], MSH2 [9], MSH6 [1], OGG1 [2], PARP1 [5], PCNA [3], POLB [2], POLD1 [1], RAD23B [3], WRN [5], XPC [2], XRCC1 [2]; MMR: EXO1 [1], LIG1 [5], MLH1 [2], MSH2 [9], MSH3 [4], MSH6 [1], PCNA [3], PMS1 [18], PMS2 [3], POLD1 [1]; SSA: ERCC1 [2], MSH2 [9], MSH3 [4], RAD52 [1]; NHEJ: LIG4 [1], PARP1 [5], XRCC4 [3], XRCC5 [4]; MMEJ: ERCC1 [2], ERCC4 [2], EXO1 [1], LIG3 [1], NBN [4], POLD1 [1], XRCC1 [2]; HR: BARD1 [1], BLM [4], BRCA1 [7], BRCA2 [5], BRIP1 [5], EXO1 [1], NBN [4], PARP1 [5], RAD51 [7], RAD52 [1], RAD54L [1], WRN [5], XRCC3 [1]; FANCONI: BLM [4], BRCA1 [7], BRCA2 [5], BRIP1 [5], ERCC1 [2], ERCC4 [2], FANCA [9]; DR: MGMT [4]; TLS: BLM [4], BRIP1 [5], FANCA [9], PCNA [3]
