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Fig. 1 | BMC Cancer

Fig. 1

From: Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade

Fig. 1

Twenty-five days after the first application of ipilimumab/nivolumab combination therapy the patient reported paraesthesia and pain in the fingertips; a slight erythema is visible on the fingertip of digitus 4 of the left hand (a). Five days after the second course ipilimumab/nivolumab combination therapy, a violaceous erythema was observed on digitus 3 and 4 of the left hand (b). Paraesthesia and pain also deteriorated

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