Table 2 Adverse events during axitinib treatment
Total (n = 98) | HbL increase <2.3 g/dL (n = 49) | HbL increase ≥2.3 g/dL (n = 49) | p | ||||
|---|---|---|---|---|---|---|---|
All grades | Grade III | All grades | Grade III | All grades | Grade III | ||
Fatigue | 61 (62) | 19 (19) | 30 (61) | 11 (22) | 30 (61) | 8 (16) | 1.00 |
Arterial hypertension | 56 (57) | 32 (33) | 21 (43) | 16 (33) | 35 (71) | 16 (33) | 0.0043 |
Diarrhoea | 55 (56) | 11 (11) | 23 (47) | 2 (4) | 31 (63) | 9 (18) | 0.10 |
Dysphonia | 36 (37) | 1 (1) | 14 (29) | 1 (2) | 22 (45) | 0 | 0.09 |
Hand-foot syndrome | 23 (23) | 9 (9) | 10 (20) | 5 (10) | 13 (26.5) | 4 (8) | 0.47 |
Anaemia | 23 (23) | 2 (2) | 15 (31) | 1 (2) | 8 (16) | 1 (2) | 0.15* |
Musculo-skeletal pain/arthralgia | 19 (19) | 2 (2) | 7 (14) | 1 (2) | 12 (24) | 1 (2) | 0.31* |
Mucositis | 17 (17) | 3 (3) | 4 (8) | 1 (2) | 13 (26.5) | 2 (4) | 0.03* |
Anorexia | 17 (17) | 4 (4) | 6 (12) | 1 (2) | 11 (22) | 3 (6) | 0.29* |
Hypothyroidism | 11 (11) | 0 | 5 (10) | 0 | 6 (12) | 0 | 1.00* |
Nausea/vomiting | 8 (8) | 1 (1) | 4 (8) | 0 | 4 (8) | 1 (2) | 1.00* |
Rash | 5 (5) | 1 (1) | 2 (4) | 0 | 3 (6) | 1 (2) | 1.00* |
Proteinuria | 2 (2) | 2 (2) | 1 (2) | 1 (2) | 1 (2) | 1 (2) | 1.00* |