Table 2 Frequency of cases and controls by clinicopathological factors
From: Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study
Number | Cases n (%) | Controls n (%) | p-value (p-value adjusting for age) | OR (CI 95%) | AOR by Age (CI 95%) | ||
|---|---|---|---|---|---|---|---|
Age (years) | < 40 | 109 | 19 (7.6) | 90 (48.4) | <0.001 | 1 | − |
40–49 | 119 | 60 (23.9) | 59 (31.7) | 4.8 (2.6–8.9)** | − | ||
50–59 | 97 | 72 (28.7) | 25 (13.4) | 13.6 (7.0–26.7)** | − | ||
≥ 60 | 112 | 100 (39.8) | 12 (6.5) | 39.5(18.2–85.8)** | − | ||
Smoker | Yes | 196 | 93 (37.7) | 103 (56.3) | <0.001 (0.446) | 0.5 (0.3–0.7)** | 0.8(0.5–1.2) |
No | 234 | 154 (62.3) | 80 (43.7) | 1 | 1 | ||
Personal BC history | Yes | 13 | 12 (4.8) | 1 (0.5) | 0.009 (0.086) | 9.3 (1.2–72.1)** | 7.0(0.8–64.7) |
No | 424 | 239 (95.2) | 185 (99.5) | 1 | 1 | ||
Number of children | 1+ | 326 | 205 (81.7) | 121 (65.1) | <0.001 (0.465) | 2.4 (1.5–3.7)** | 1.0 (0.6–1.8) |
None | 111 | 46 (18.3) | 65 (34.9) | 1 | 1 | ||
Breastfeeding (months) | 12+ | 81 | 52 (27.2) | 29 (25.2) | 0.789 (0.139) | 1.1 (0.6–1.9) | 0.8 (0.4–1.5) |
0–11 | 170 | 139 (72.8) | 86 (74.8) | 1 | 1 | ||
Menopausial status | Yes | 188 | 152 (62.0) | 36 (19.7) | <0.001 (0.238) | 6.7 (4.2–10.4)** | 0.7 (0.3–1.6) |
No | 240 | 93 (38.0) | 147 (80.3) | 1 | 1 | ||
Age at menopause (years) | ≥ 54 | 25 | 24 (15.8) | 1(2.8) | 0.012 (0.179) | 18 (1.9–173)** | 7.5 (0.7–82.6) |
42–53 | 149 | 120 (78.9) | 29 (80.6)* | 3.1 (0.9–9.6)* | 1.8 (0.5–6.9) | ||
≤ 41 | 14 | 8(5.3) | 6 (16.7) | 1 | 1 | ||
History of cervical diseases | No | 302 | 156 (95.7) | 146 (91.8) | 0.171 (0.288) | 1.9 (0.8–5.1) | 1.7 (0.6–4.8) |
Yes | 20 | 7 (4.3) | 13 (8.2) | 1 | 1 | ||