Thrombophilia | ALL or Chemotherapeutic agent | Possible interaction |
---|---|---|
PT gene polymorphism 20210A | ALL | PT mutation may exaggerate ALL-induced thrombin generation |
Corticosteroid | May induce higher levels of PT | |
MTHFR C677T | Methotrexate | By inhibiting folate pathway induces functional MTHFR deficiency even in heterozygous patients with resultant high Hcy levels |
FVL | Asparaginase | By reducing protein C levels may exaggerate the effects of FVL even in heterozygous subjects |
Protein C, S and AT deficiency | Asparaginase | By inhibiting protein synthesis results in reduction in Proteins C, S and AT |
Elevated pro-coagulant factors VIII:C, IX and XI | Corticosteroid | May induce higher levels of factors VIII:C, IX and XI |
Elevated Lp(a) levels | Asparaginase | Lead to mark elevation in Lp(a) |