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Table 3 Correlations between the severity of microvascular invasion or portal vein tumor thrombus and viral features in hepatocellular carcinomaa

From: Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma

HBV-related factors Severity of MVI P Classification of PVTT P
None (%) Mild (%) Severe (%) None (%) I/II (%) III/IV (%)
Seral HBsAg
 Positive 171 (83.8) 127 (89.4) 131 (94.9) 0.005* 326 (86.2) 74 (94.9) 30 (100) 0.007*
 Negative 33 (16.2) 15 (10.6) 7 (5.1)   52 (13.8) 4 (5.1) 0 (0)  
Seral HBeAg
 Positive 37 (21.6) 38 (29.9) 48 (36.6) 0.016* 84 (25.8) 30 (40.5) 9 (30) 0.04*
 Negative 134 (78.4) 89 (60.1) 83 (63.4)   242 (74.2) 44 (59.5) 21 (70)  
Seral HBV DNA load
  > 50 IU/ml 99 (57.9) 90 (70.9) 106 (80.9) <0.001* 219 (67.2) 52 (70.3) 24 (80) 0.355
  < = 50 IU/ml) 72 (42.1) 37 (29.1) 25 (19.1)   107 (32.8) 22 (29.7) 6 (20)  
Presence of cirrhosis
 Yes 52 (30.4) 48 (37.8) 44 (33.6) 0.418 96 (29.4) 32 (43.2) 16 (53.3) 0.005*
 No 119 (69.6) 79 (62.2) 87 (66.4)   230 (60.6) 42 (56.8) 14 (46.7)  
Antivirus treatment
 Yes 66 (38.6) 36 (28.3) 26 (19.8) 0.002* 109 (33.4) 15 (20.3) 4 (13.3) 0.009*
 No 105 (61.4) 91 (61.7) 105 (80.2)   217 (66.6) 59 (79.7) 26 (86.7)  
  1. HBV Hepatitis B virus; HBsAg Hepatitis B virus s Antigen; HBeAg Hepatitis B virus e Antigen
  2. aanalysis was only carried out in patients with positive HBsAg except the “HBsAg” row
  3. *P < 0.05