Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma

Wei, Xubiao; Li, Nan; Li, Shanshan; Shi, Jie; Guo, Weixing; Zheng, Yaxin; Cheng, Shuqun

doi:10.1186/s12885-017-3293-6

Table 1 Univariate analysis of risk factors for formation of vascular invasion in hepatocellular carcinoma patients who underwent hepatectomy

From: Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma

Parameters	Vascular invasion		P	MVI		P	PVTT		P
Parameters	yes	no		yes	no		yes	no
Patient demographics
Age
> 50 years	153	125	0.006*	149	129	0.017*	53	225	0.053
< = 50 years	140	68		134	74		55	153
Gender
Male	255	167	0.873	245	177	0.842	99	323	0.092
Female	38	26		38	26		9	55
Preoperative laboratory test
Total bilirubin
> 20 μmol/l	48	32	0.954	48	32	0.725	16	64	0.601
< = 20 umol/l	245	161		235	171		92	314
ALT
> 42 U/l	128	83	0.882	122	89	0.872	49	162	0.642
< = 42 U/l	165	110		161	114		59	216
AST,
> 37 U/l	157	114	0.234	152	119	0.282	62	209	0.696
< = 37 U/l	136	79		131	84		46	169
Albumin
> 40 g/l	193	100	0.734	188	135	0.987	67	256	0.270
< = 40 g/l	130	63		95	68		41	122
DCP
> 100 mAU/ml	250	147	0.011*	241	156	0.019*	102	295	<0.001*
< = 100 mAU/ml	43	46		42	47		6	83
Alpha-fetoprotein
> 20 ng/ml	226	102	<0.001*	219	109	<0.001*	85	243	0.005*
< = 20 ng/ml	67	91		64	94		23	135
Tumor characteristics
Diameter
> 3 cm	247	138	0.001*	238	147	0.002*	105	280	<0.001*
< = 3 cm	46	55		45	56		3	98
Number of lesions
Multiple	43	15	0.022*	41	17	0.040*	20	38	0.017*
Single	250	178		242	186		88	340
Encapsulation
Incomplete/absent	259	145	<0.001*	250	154	<0.001*	101	303	0.001*
Complete	34	48		33	49		7	75
Edmonson grading
Grades III/IV	277	151	<0.001*	267	161	<0.001*	101	327	0.047*
Grades I/II	16	42		16	42		7	51
Virus-related factors
Seral HBsAg
Positive	269	161	0.005*	260	170	0.006*	104	326	0.003*
Negative	24	32		23	33		4	52
Seral HBeAg
Positive	93	32	<0.001*	88	37	0.002*	39	86	0.005*
Negative	200	160		195	165		69	291
HBV DNA load
Detectable (> 50 IU/ml)	203	94	<0.001*	197	100	<0.001*	76	221	0.025*
Undetectable (<=50 IU/ml)	90	99		86	103		32	157
High (> 2000 IU/ml)	110	62	0.222	106	66	0.261	39	133	0.859
Low (<= 2000 IU/ml)	183	131		177	137		69	39
Presence of cirrhosis
Yes	101	52	0.08	96	57	0.171	49	104	<0.001*
No	192	141		187	146		59	274
Anti-virus treatment
Yes	64	66	0.003*	63	67	0.008*	19	111	0.015*
No	229	127		220	136		89	267

MVI Microvascular invasion; PVTT Portal vein tumor thrombus; ALT Alanine aminotransferase; AST Aspartate aminotransferase; DCP Des-gamma-carboxy prothrombin; HBsAg Hepatitis B virus s Antigen; HBeAg Hepatitis B virus e Antigen; HBV Hepatitis B virus
*P < 0.05

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ISSN: 1471-2407

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