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Table 1 Univariate analysis of risk factors for formation of vascular invasion in hepatocellular carcinoma patients who underwent hepatectomy

From: Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma

Parameters Vascular invasion P MVI P PVTT P
yes no   yes no   yes no  
Patient demographics
Age
 > 50 years 153 125 0.006* 149 129 0.017* 53 225 0.053
 < = 50 years 140 68   134 74   55 153  
Gender
 Male 255 167 0.873 245 177 0.842 99 323 0.092
 Female 38 26   38 26   9 55  
Preoperative laboratory test
Total bilirubin
 > 20 μmol/l 48 32 0.954 48 32 0.725 16 64 0.601
 < = 20 umol/l 245 161   235 171   92 314  
ALT
 > 42 U/l 128 83 0.882 122 89 0.872 49 162 0.642
 < = 42 U/l 165 110   161 114   59 216  
AST,
 > 37 U/l 157 114 0.234 152 119 0.282 62 209 0.696
 < = 37 U/l 136 79   131 84   46 169  
Albumin
 > 40 g/l 193 100 0.734 188 135 0.987 67 256 0.270
 < = 40 g/l 130 63   95 68   41 122  
DCP
 > 100 mAU/ml 250 147 0.011* 241 156 0.019* 102 295 <0.001*
 < = 100 mAU/ml 43 46   42 47   6 83  
Alpha-fetoprotein
 > 20 ng/ml 226 102 <0.001* 219 109 <0.001* 85 243 0.005*
 < = 20 ng/ml 67 91   64 94   23 135  
Tumor characteristics
Diameter
 > 3 cm 247 138 0.001* 238 147 0.002* 105 280 <0.001*
 < = 3 cm 46 55   45 56   3 98  
Number of lesions
 Multiple 43 15 0.022* 41 17 0.040* 20 38 0.017*
 Single 250 178   242 186   88 340  
Encapsulation
 Incomplete/absent 259 145 <0.001* 250 154 <0.001* 101 303 0.001*
 Complete 34 48   33 49   7 75  
Edmonson grading
 Grades III/IV 277 151 <0.001* 267 161 <0.001* 101 327 0.047*
 Grades I/II 16 42   16 42   7 51  
Virus-related factors
 Seral HBsAg
  Positive 269 161 0.005* 260 170 0.006* 104 326 0.003*
  Negative 24 32   23 33   4 52  
 Seral HBeAg
 Positive 93 32 <0.001* 88 37 0.002* 39 86 0.005*
 Negative 200 160   195 165   69 291  
HBV DNA load
 Detectable (> 50 IU/ml) 203 94 <0.001* 197 100 <0.001* 76 221 0.025*
 Undetectable (<=50 IU/ml) 90 99   86 103   32 157  
 High (> 2000 IU/ml) 110 62 0.222 106 66 0.261 39 133 0.859
 Low (<= 2000 IU/ml) 183 131   177 137   69 39  
Presence of cirrhosis
 Yes 101 52 0.08 96 57 0.171 49 104 <0.001*
 No 192 141   187 146   59 274  
Anti-virus treatment
 Yes 64 66 0.003* 63 67 0.008* 19 111 0.015*
 No 229 127   220 136   89 267  
  1. MVI Microvascular invasion; PVTT Portal vein tumor thrombus; ALT Alanine aminotransferase; AST Aspartate aminotransferase; DCP Des-gamma-carboxy prothrombin; HBsAg Hepatitis B virus s Antigen; HBeAg Hepatitis B virus e Antigen; HBV Hepatitis B virus
  2. *P < 0.05