Fig. 4

Illustration presenting the three indicated staining patterns and their distribution among the samples. a) Illustration of the three characteristic MX35 staining patterns identified among the samples; Pattern a, the target was located in the cell membranes of the cells close to the surface of the tumor (serous borderline, stage I). Pattern b, MX35 staining in all of the tumor cell membranes over the entire tumor (clear cell highly differentiated, stage I). Pattern c, includes the tumors with a mixed staining pattern including staining of membranes in addition to cytoplasmic staining spreading inside the as well (serous poorly differentiated stage I). The right panel shows images with higher magnification to give a more detailed view of the three patterns. b) The distribution of the tumor samples, malignant and borderline, between the three patterns. c) The tumors divided based on pattern, presented according to their histology