SNP | Nearest gene | Â | Favorable Energy Balance Group | Unfavorable Energy Balance Group | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Direct effect | Indirect effect | Total effect | Direct effect | Indirect effect | Total effect | |||||||||
Effect allele/Other allele | CRC risk in relation to SNP through pathways other than glucose | CRC risk in relation to SNP through glucose | CRC risk in relation to SNP | CRC risk in relation to SNP through pathways other than glucose | CRC risk in relation to SNP through glucose | CRC risk in relation to SNP | ||||||||
 | HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | ||
BMIb | ||||||||||||||
 rs4607517 | GCK | G/A | 0.79 | (0.60–1.02) | 0.02 | (0.002–0.04) | 0.80 | (0.64–1.00) | 1.00 | (0.65–1.55) | 0.001 | (−0.01–0.01) | 1.06 | (0.75–1.51) |
 rs174550 | FADS1 | T/C | 1.15 | (0.92–1.43) | −0.002 | (−0.01–0.01) | 1.05 | (0.87–1.27) | 1.40 | (0.97–2.03) | <0.001 | (−0.01–0.01) | 1.37 | (1.02–1.83) |
 rs11605924 | CRY2 | C/A | 0.89 | (0.73–1.09) | −0.004 | (−0.01–0.02) | 0.82 | (0.69–0.98) | 1.32 | (0.94–1.85) | <0.001 | (−0.004–0.004) | 1.07 | (0.82–1.39) |
Waistc | ||||||||||||||
 rs560887 | G6PC2 | T/C | 0.75 | (0.58–0.99) | 0.01 | (−0.03–0.004) | 0.88 | (0.70–1.11) | 1.00 | (0.75–1.34) | 0.01 | (−0.04–0.02) | 1.01 | (0.80–1.27) |
 rs174550 | FADS1 | T/C | 1.17 | (0.91–1.51) | −0.01 | (−0.02–0.01) | 1.03 | (0.83–1.28) | 1.23 | (0.93–1.63) | 0.01 | (−0.01–0.02) | 1.25 | (1.00–1.57) |
 rs11605924 | CRY2 | C/A | 0.84 | (0.67–1.06) | −0.01 | (−0.01–0.02) | 0.81 | (0.66–0.99) | 1.20 | (0.92–1.56) | 0.004 | (−0.02–0.01) | 0.97 | (0.79–1.20) |
w/h Ratiod | ||||||||||||||
 rs10885122 | ADRA2A | G/T | 0.80 | (0.59–1.07) | −0.002 | (−0.01–0.01) | 0.84 | (0.64–1.08) | 1.36 | (0.81–2.30) | <0.001 | (−0.003–0.003) | 1.58 | (1.01–2.48) |
Physical activity levele | ||||||||||||||
 rs4607517 | GCK | G/A | 0.73 | (0.52–1.00) | 0.01 | (−0.01–0.04) | 0.72 | (0.55–0.95) | 0.95 | (0.70–1.31) | 0.01 | (−0.01–0.02) | 0.99 | (0.76–1.28) |
Dietary fat intakef | ||||||||||||||
 rs4607517 | GCK | G/A | 0.91 | (0.71–1.17) | 0.01 | (−0.004–0.03) | 0.94 | (0.76–1.17) | 0.57 | (0.33–1.01) | −0.003 | (−0.01–0.01) | 0.66 | (0.43–1.00) |
 rs11558471 | SLC30A8 | A/G | 1.07 | (0.87–1.31) | −0.02 | (−0.04–0.004) | 0.95 | (0.80–1.12) | 1.60 | (0.93–2.75) | −0.002 | (−0.01–0.01) | 1.60 | (1.07–2.40) |