SNP | Nearest gene | Effect allele/Other allele | Favorable Energy Balance Group | Unfavorable Energy Balance Group | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Direct effect | Indirect effect | Total effect | Direct effect | Indirect effect | Total effect | |||||||||
Breast cancer risk in relation to SNP through pathways other than glucose | Breast cancer risk in relation to SNP through glucose | Breast cancer risk in relation to SNP | Breast cancer risk in relation to SNP through pathways other than glucose | Breast cancer risk in relation to SNP through glucose | Breast cancer risk in relation to SNP | |||||||||
HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | HRa | 95% CI | Effect sizea | 95% CI | HRa | 95% CI | |||
BMIb | ||||||||||||||
 rs560887 | G6PC2 | T/C | 1.11 | (0.89–1.39) | 0.01 | (−0.04–0.02) | 1.12 | (0.90–1.39) | 1.34 | (1.04–1.73) | −0.004 | (−0.01–0.02) | 1.35 | (1.05–1.74) |
Waistc | ||||||||||||||
 rs560887 | G6PC2 | T/C | 1.09 | (0.85–1.39) | 0.004 | (−0.02–0.01) | 1.10 | (0.86–1.40) | 1.35 | (1.07–1.70) | −0.01 | (−0.01–0.02) | 1.33 | (1.06–1.66) |
w/h Ratiod | ||||||||||||||
 rs560887 | G6PC2 | T/C | 1.07 | (0.89–1.39) | 0.01 | (−0.03–0.01) | 1.10 | (0.89–1.36) | 1.47 | (1.13–1.92) | −0.003 | (−0.003–0.01) | 1.42 | (1.10–1.85) |
 rs780094 | GCKR | C/T | 1.01 | (0.82–1.23) | −0.01 | (−0.03–0.01) | 1.02 | (0.84–1.24) | 1.33 | (1.00–1.76) | 0.002 | (−0.003–0.01) | 1.22 | (0.93–1.60) |
 rs35767 | IGF1 | A/G | 0.91 | (0.68–1.21) | 0.002 | (−0.01–0.004) | 0.93 | (0.70–1.23) | 1.43 | (1.03–1.98) | <0.001 | (−0.004–0.004) | 1.48 | (1.08–2.03) |
Dietary fat intakee | ||||||||||||||
 rs560887 | G6PC2 | T/C | 1.14 | (0.95–1.37) | −0.01 | (−0.003–0.02) | 1.14 | (0.95–1.37) | 1.56 | (1.07–2.28) | 0.02 | (−0.07–0.03) | 1.59 | (1.10–2.31) |