Fig. 1From: Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal womenDiagrams of total, direct, and indirect pathways of SNPs in glucose metabolism genes, glucose metabolism traits, and cancer risk. (HOMA-IR, homeostatic model assessment–insulin resistance; HR, hazard ratio; SNP, single-nucleotide polymorphism.). a C is a total effect (overall genetic effect, without considering the effect of glucose metabolism traits), expressed via HR. b C′ is a direct effect (cancer risk associated with glucose metabolism-relevant genetic variants through pathways other than glucose metabolism traits), expressed via HR after accounting for mediator; a*b (≈C-C′) is an indirect effect (cancer risk associated with glucose metabolism-relevant genetic variants through pathways mediated by glucose metabolism traits)Back to article page