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Fig. 1 | BMC Cancer

Fig. 1

From: Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women

Fig. 1

Diagrams of total, direct, and indirect pathways of SNPs in glucose metabolism genes, glucose metabolism traits, and cancer risk. (HOMA-IR, homeostatic model assessment–insulin resistance; HR, hazard ratio; SNP, single-nucleotide polymorphism.). a C is a total effect (overall genetic effect, without considering the effect of glucose metabolism traits), expressed via HR. b C′ is a direct effect (cancer risk associated with glucose metabolism-relevant genetic variants through pathways other than glucose metabolism traits), expressed via HR after accounting for mediator; a*b (≈C-C′) is an indirect effect (cancer risk associated with glucose metabolism-relevant genetic variants through pathways mediated by glucose metabolism traits)

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