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Table 4 Risk of Death in Patients with Unresectable Malignant Biliary Obstruction after Therapy

From: The safety and efficacy of percutaneous intraductal radiofrequency ablation in unresectable malignant biliary obstruction: A single-institution experience

  

Univariate Analysis

Multivariate Analysis

Variable*

No. of cases

HR(95%CI)

P†

HR(95%CI)

P

Age(≥62 y vs < 62 y)

25/25

0.776(0.379,1.589)

0.488

  

Sex(male vs female)

36/14

0.803(0.475,1.359)

0.414

  

Tumor diagnosis (Cholangiocarcinoma vs other neoplasms)

25/25

0.825(0.439,1.552)

0.552

  

Type of obstruction(proximal vs distal)

19/31

0.932(0.490,1.775)

0.825

  

Performance status score (2 vs ≤1)

32/18

1.706(0.890,3.270)

0.108

  

No. of interventions (1 vs ≥2)

42/8

0.187(0.055,0.630)

0.007

0.295(0.106,0.818)

0.019

Previously cholangeitis (no vs yes)

28/22

0.794(0.405,1.555)

0.500

  

Distant Metastasis(yes vs no)

29/21

0.897(0.474,1.698)

0.739

  

Chemotherapy (no vs yes)

43/7

0.273(0.094,0.792)

0.017

2.0.465 (0.159,1.365)

0.164

TB(≥168.0 μmol/L vs <168.0 μmol/L)

25/25

1.038(0.544,1.978)

0.911

  

DB(≥95.1 μmol/L vs < 95.1 μmol/L)

25/25

0.901(0.475,1.706)

0.748

  

ALT (≥71 U/L vs <71 U/L)

25/25

1.495(0.791,2.825)

0.216

  

AST (≥72.5 U/L vs < 72.5 U/L)

25/25

1.087(0.575,2.056)

0.798

  

GGT(≥311 U/L vs < 311 U/L)

25/25

1.100(0.584,2.072)

0.767

  
  1. Note—TB = total bilirubin, DB = direct bilirubin, ALT = alanine aminotransferase, AST = aspartate aminotransferase, G-GT = gamma-glutamyl transpeptidase
  2. *For continuous variables, cutoff level chosen for continuous variables was their median value
  3. P values were determined with Cox proportional hazards regression models. P < 0 .05 indicated a significant difference