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Table 4 Risk of Death in Patients with Unresectable Malignant Biliary Obstruction after Therapy

From: The safety and efficacy of percutaneous intraductal radiofrequency ablation in unresectable malignant biliary obstruction: A single-institution experience

   Univariate Analysis Multivariate Analysis
Variable* No. of cases HR(95%CI) P† HR(95%CI) P
Age(≥62 y vs < 62 y) 25/25 0.776(0.379,1.589) 0.488   
Sex(male vs female) 36/14 0.803(0.475,1.359) 0.414   
Tumor diagnosis (Cholangiocarcinoma vs other neoplasms) 25/25 0.825(0.439,1.552) 0.552   
Type of obstruction(proximal vs distal) 19/31 0.932(0.490,1.775) 0.825   
Performance status score (2 vs ≤1) 32/18 1.706(0.890,3.270) 0.108   
No. of interventions (1 vs ≥2) 42/8 0.187(0.055,0.630) 0.007 0.295(0.106,0.818) 0.019
Previously cholangeitis (no vs yes) 28/22 0.794(0.405,1.555) 0.500   
Distant Metastasis(yes vs no) 29/21 0.897(0.474,1.698) 0.739   
Chemotherapy (no vs yes) 43/7 0.273(0.094,0.792) 0.017 2.0.465 (0.159,1.365) 0.164
TB(≥168.0 μmol/L vs <168.0 μmol/L) 25/25 1.038(0.544,1.978) 0.911   
DB(≥95.1 μmol/L vs < 95.1 μmol/L) 25/25 0.901(0.475,1.706) 0.748   
ALT (≥71 U/L vs <71 U/L) 25/25 1.495(0.791,2.825) 0.216   
AST (≥72.5 U/L vs < 72.5 U/L) 25/25 1.087(0.575,2.056) 0.798   
GGT(≥311 U/L vs < 311 U/L) 25/25 1.100(0.584,2.072) 0.767   
  1. Note—TB = total bilirubin, DB = direct bilirubin, ALT = alanine aminotransferase, AST = aspartate aminotransferase, G-GT = gamma-glutamyl transpeptidase
  2. *For continuous variables, cutoff level chosen for continuous variables was their median value
  3. P values were determined with Cox proportional hazards regression models. P < 0 .05 indicated a significant difference