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Table 3 Risk of Recurrence of Biliary Obstruction in Patients with Unresectable Malignant Biliary Obstruction after Therapy

From: The safety and efficacy of percutaneous intraductal radiofrequency ablation in unresectable malignant biliary obstruction: A single-institution experience

   Univariate Analysis Multivariate Analysis
Variable* No. of cases HR(95%CI) P† HR(95%CI) P
Age(≥62 y vs < 62 y) 25/25 2.348(0.840,6.566) 0.104   
Sex(male vs female) 36/14 1.243(0.404,3.827) 0.705   
Tumor diagnosis (Cholangiocarcinoma vs other neoplasms) 25/25 1.770(0.679,4.612) 0.243   
Type of obstruction(proximal vs distal) 19/31 0.899(0.324,2.494) 0.838   
Performance status score (2 vs ≤1) 32/18 1.706(0.890,3.270) 0.108   
Previously cholangeitis (no vs yes) 28/22 3.347(1.176,9.525) 0.024 3.347(1.176,9.525) 0.024
Distant Metastasis(yes vs no) 29/21 1.292(0.490,3.403) 0.605   
Chemotherapy (no vs yes) 43/7 0.840(0.277,2.547) 0.759   
TB(≥168.0 μmol/L vs <168.0 μmol/L) 25/25 0.488(0.184,1.294) 0.149   
DB(≥95.1 μmol/L vs < 95.1 μmol/L) 25/25 0.485(0.183,1.287) 0.146   
ALT (≥71 U/L vs <71 U/L) 25/25 1.352(0.491,3.728) 0.560   
AST (≥72.5 U/L vs < 72.5 U/L) 25/25 0.887(0.348,2.261) 0.801   
GGT(≥311 U/L vs < 311 U/L) 25/25 0.613(0.228,1.652) 0.334   
  1. Note—TB = total bilirubin, DB = direct bilirubin, ALT = alanine aminotransferase, AST = aspartate aminotransferase, G-GT = gamma-glutamyl transpeptidase
  2. *For continuous variables, cutoff level chosen for continuous variables was their median value
  3. P values were determined with Cox proportional hazards regression models. P < 0 .05 indicated a significant difference