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Table 1 Contrast-enhanced US performed according to theperfluorobutane(Sonazoid) protocol

From: Contrast-enhanced US with Perfluorobutane(Sonazoid) used as a surveillance test for Hepatocellular Carcinoma (HCC) in Cirrhosis (SCAN): an exploratory cross-sectional study for a diagnostic trial

Imaging protocol
Intravenous access Antecubital or forearm
Contrast preparation 16 μg of perfluorobutane dissolved in 2 mL of sterile water
Injection dose 0.015 mL/kg body weight
Injection method Bolus with 10-mL normal saline flush
Contrast US setting
 Scanning view Dual view ( B-mode + contrast mode)
 Mechanical index 0.20 -0.26
 Dynamic range 60 - 65dB
 Location of the beam focus Posterior margin of the liver
 Contrast harmonic imaging Used
Kupffer phase 10 to 15 minutes after the injection of perfluorobutane
Vascular phase After reinjection of perfluorobutane
 Artery phase 10-40 seconds
 Portal phase 60-90 seconds
 Delay phase 3–4 minutes