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Table 1 Contrast-enhanced US performed according to theperfluorobutane(Sonazoid) protocol

From: Contrast-enhanced US with Perfluorobutane(Sonazoid) used as a surveillance test for Hepatocellular Carcinoma (HCC) in Cirrhosis (SCAN): an exploratory cross-sectional study for a diagnostic trial

Imaging protocol

Intravenous access

Antecubital or forearm

Contrast preparation

16 μg of perfluorobutane dissolved in 2 mL of sterile water

Injection dose

0.015 mL/kg body weight

Injection method

Bolus with 10-mL normal saline flush

Contrast US setting

 Scanning view

Dual view ( B-mode + contrast mode)

 Mechanical index

0.20 -0.26

 Dynamic range

60 - 65dB

 Location of the beam focus

Posterior margin of the liver

 Contrast harmonic imaging

Used

Kupffer phase

10 to 15 minutes after the injection of perfluorobutane

Vascular phase

After reinjection of perfluorobutane

 Artery phase

10-40 seconds

 Portal phase

60-90 seconds

 Delay phase

3–4 minutes