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Table 1 Immunohistochemistry profile at the time of first evaluation

From: Alpha–fetoprotein elevation in NUT midline carcinoma: a case report

Weakly positive

Clues to diagnosis (if positive)

Negative

Clues to diagnosis (if positive)

AE1-AE3 cytokeratin pool

Carcinomas, GCT (rare), thymoma, mesenchymal tumors

PLAP

Seminoma

TTF-1

Lung, thyroid cancer

AFP

Non-seminoma GCT, HCC, pancreas carcinoma

p63

Basal/squamous carcinoma, mesenchymal tumors, lymphomas, adenoid cystic carcinoma, salivary gland tumors, thymoma, thymic carcinoma, breast, urothelial carcinoma

Beta-HCG

Non-seminoma GCT

Synaptophysin

Neuroendocrine neoplasms, adrenal gland carcinoma, mesenchymal tumors

CD30

Lymphomas (HL and NHL), non-seminoma GCT,

Chromogranin A

Neuroendocrine tumors

CD3

T-cell lymphomas

CD34

Hematologic malignances, mesenchymal tumors, papillary thyroid carcinoma, thymoma

CD20

B-cell lymphomas

Focally positive

 

CD117

Mesenchymal tumors, GCT, SCLC, leukemias, lymphomas, melanoma

EMA

adenocarcinoma, renal cell carcinoma, choriocarcinoma, mesenchymal tumors, mesothelioma, lymphoma, thymic carcinoma

Melan-A

Melanoma, mesenchymal tumors, adrenal cortical tumors, sex-cord stromal tumors

Cytokeratin 7

Lung cancer and other carcinomas, GCT (rare), mesenchymal tumors

S-100

Melanoma, mesenchymal tumors, adenoid cystic carcinoma, sex-cord stromal tumors

  

ALK

Lymphomas, NSCLC, mesenchymal tumors, RCC (rare)

  

PAX8

Thymic carcinoma, thymomas, thyroid anaplastic carcinoma, RCC, neuroendocrine neoplasms, seminoma

  

Desmin

Mesenchymal tumors

  1. TTF-1 thyroid transcription factor-1, EMA epithelial membrane antigen, PLAP placental alkaline phosphatase, AFP alpha-fetoprotein, beta-HCG human chorionic gonadotropin, ALK anaplastic lymphoma kinase, GCT germ cell tumor, HCC hepatocellular carcinoma, HL Hodgkin’s lymphoma, NHL Non-Hodgkin lymphoma, RCC renal cell carcinoma, SCLC small cell lung cancer, NSCLC non-small cell lung cancer