From: Alpha–fetoprotein elevation in NUT midline carcinoma: a case report
Weakly positive | Clues to diagnosis (if positive) | Negative | Clues to diagnosis (if positive) |
---|---|---|---|
AE1-AE3 cytokeratin pool | Carcinomas, GCT (rare), thymoma, mesenchymal tumors | PLAP | Seminoma |
TTF-1 | Lung, thyroid cancer | AFP | Non-seminoma GCT, HCC, pancreas carcinoma |
p63 | Basal/squamous carcinoma, mesenchymal tumors, lymphomas, adenoid cystic carcinoma, salivary gland tumors, thymoma, thymic carcinoma, breast, urothelial carcinoma | Beta-HCG | Non-seminoma GCT |
Synaptophysin | Neuroendocrine neoplasms, adrenal gland carcinoma, mesenchymal tumors | CD30 | Lymphomas (HL and NHL), non-seminoma GCT, |
Chromogranin A | Neuroendocrine tumors | CD3 | T-cell lymphomas |
CD34 | Hematologic malignances, mesenchymal tumors, papillary thyroid carcinoma, thymoma | CD20 | B-cell lymphomas |
Focally positive | CD117 | Mesenchymal tumors, GCT, SCLC, leukemias, lymphomas, melanoma | |
EMA | adenocarcinoma, renal cell carcinoma, choriocarcinoma, mesenchymal tumors, mesothelioma, lymphoma, thymic carcinoma | Melan-A | Melanoma, mesenchymal tumors, adrenal cortical tumors, sex-cord stromal tumors |
Cytokeratin 7 | Lung cancer and other carcinomas, GCT (rare), mesenchymal tumors | S-100 | Melanoma, mesenchymal tumors, adenoid cystic carcinoma, sex-cord stromal tumors |
ALK | Lymphomas, NSCLC, mesenchymal tumors, RCC (rare) | ||
PAX8 | Thymic carcinoma, thymomas, thyroid anaplastic carcinoma, RCC, neuroendocrine neoplasms, seminoma | ||
Desmin | Mesenchymal tumors |