Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García-Rivello, Hernán; Wernicke, Alejandra; Feldman, Leonardo; Matas, Ayelén; Giorello, María Belén; Borzone, Francisco Raúl; Choi, Hosoon; Howard, Scott C.; Chasseing, Norma Alejandra

doi:10.1186/s12885-017-3259-8

Table 5 Association of the levels of expression of OPG, TRAIL, RANKL, SDF-1, IL-6, and CCL-2 in spindle-shaped stroma cells (not associated with the vasculature) with the clinicopathological characteristics of patients with early invasive ductal breast cancer

From: Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Characteristics		Ligands in spindle-shaped stromal cells
		OPG		TRAIL		RANKL		SDF-1		IL-6		CCL-2
		High expression %	p	High expression %	p	High expression %	p	High expression %	p	High expression %	p	High expression %	p
Age (years)	<50	50.0	0.742	66.7	0.137	70.0	0.709	40.0	0.493	22.2	0.664	22.2	0.646
Age (years)	≥50	44.0	0.742	35.3	0.137	75.0	0.709	55.8	0.493	17.6	0.664	16.3	0.646
Tumor size (cm)	<2	48.8	0.255	38.1	>0.999	68.2	0.193	56.8	0.391	21.4	0.483	19.5	0.708
Tumor size (cm)	≥2	31.2	0.255	41.2	>0.999	88.2	0.193	41.2	0.391	11.8	0.483	12.5	0.708
Histological grade	G1	60.0	0.336	35.7	0.518	60.0	0.491	66.7	0.042*	21.4	0.741	33.3	0.116
	G2	35.0		50.0		76.2		66.7		20.0		5.3
	G3	39.1		33.3		79.2		33.3		12.5		17.4
HER2/neu status	Negative	44.4	>0.999	44.7	0.272	78.9	0.368	57.9	0.302	18.4	>0.999	17.1	>0.999
HER2/neu status	Positive	43.5	>0.999	28.6	0.272	65.2	0.368	43.5	0.302	19.0	>0.999	18.2	>0.999
ER status	Negative	46.7	>0.999	42.9	0.761	80.0	0.738	53.3	>0.999	21.4	>0.999	20.0	>0.999
ER status	Positive	43.2	>0.999	37.8	0.761	71.7	0.738	52.2	>0.999	17.8	>0.999	16.7	>0.999
PR status	Negative	42.9	>0.999	30.8	0.540	78.6	0.742	50.0	>0.999	15.4	>0.999	7.1	0.422
PR status	Positive	44.4	>0.999	41.3	0.540	72.3	0.742	53.2	>0.999	19.6	>0.999	20.9	0.422
Regional lymph nodes	Negative	46.1	0.547	41.5	>0.999	74.4	0.745	55.8	0.773	17.1	>0.999	19.0	0.724
Regional lymph nodes	Positive	35.7	0.547	37.5	>0.999	68.7	0.745	50.0	0.773	18.7	>0.999	14.3	0.724
Metastatic occurrence	Negative	32.5	0.038*	34.9	0.072	65.9	0.146	47.3	0.745	11.6	0.163	9.1	0.049*
Metastatic occurrence	Positive	70.0	0.038*	70.0	0.072	90.9	0.146	54.5	0.745	30.0	0.163	36.4	0.049*
Local relapse	Negative	39.6	>0.999	42.9	0.633	72.0	0.621	50.0	>0.999	16.3	0.612	14.9	>0.999
Local relapse	Positive	40.0	>0.999	25.0	0.633	60.0	0.621	40.0	>0.999	0.0	0.612	20.0	>0.999

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ISSN: 1471-2407

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