Table 4 Association of the levels of expression of TRAIL-R1-R4, RANK, CXCR-4, IL-6R, and CCR-2 in TEpCs with the clinicopathological characteristics of patients with early invasive ductal breast cancer
Characteristics | Receptors in TEpC | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TRAIL-R1 | TRAIL-R2 | TRAIL-R3 | TRAIL-R4 | RANK | CXCR-4 | IL-6-R | CCR-2 | ||||||||||
High expression % | p | High expression % | p | High expression % | p | High expression % | p | High expression % | p | High expression % | p | High expression % | p | High expression % | p | ||
Age (years) | <50 | 87.5 | 0.249 | 0.0 | >0.999 | 40.0 | 0.729 | 80.0 | 0.175 | 30.0 | 0.176 | 50.0 | 0.259 | 75.0 | 0.042* | 11.1 | >0.999 |
≥50 | 63.5 | 9.6 | 34.0 | 54.7 | 55.8 | 73.1 | 31.3 | 12.0 | |||||||||
Tumor size (cm) | <2 | 66.7 | >0.999 | 9.3 | >0.999 | 35.6 | >0.999 | 57.8 | >0.999 | 50.0 | 0.579 | 68.2 | >0.999 | 31.6 | 0.365 | 11.9 | >0.999 |
≥2 | 64.7 | 5.9 | 35.3 | 58.8 | 58.8 | 70.6 | 47.1 | 12.5 | |||||||||
Histological grade | G1 | 71.4 | 0.397 | 13.3 | 0.245 | 33.3 | >0.999 | 60.0 | 0.803 | 53.3 | >0.999 | 66.7 | 0.941 | 38.5 | 0.078 | 20.0 | 0.597 |
G2 | 55.0 | 0.0 | 36.7 | 63.6 | 52.4 | 71.4 | 16.7 | 10.0 | |||||||||
G3 | 75.0 | 12.5 | 37.5 | 54.2 | 50.0 | 66.7 | 50.0 | 8.7 | |||||||||
HER2/neu status | Negative | 59.5 | 0.255 | 5.4 | 0.361 | 25.6 | 0.054 | 51.3 | 0.190 | 52.6 | >0.999 | 71.0 | 0.776 | 26.5 | 0.083 | 16.7 | 0.235 |
Positive | 77.3 | 13.0 | 52.2 | 69.6 | 52.2 | 65.2 | 52.4 | 4.5 | |||||||||
ER status | Negative | 66.7 | >0.999 | 13.3 | 0.590 | 53.3 | 0.125 | 60.0 | >0.999 | 60.0 | 0.562 | 73.3 | 0.757 | 46.7 | 0.361 | 20.0 | 0.359 |
Positive | 65.9 | 6.7 | 29.8 | 57.4 | 50.0 | 67.4 | 32.5 | 9.3 | |||||||||
PR status | Negative | 64.3 | >0.999 | 14.3 | 0.581 | 42.9 | 0.539 | 57.1 | >0.999 | 57.1 | 0.766 | 78.6 | 0.516 | 35.7 | >0.999 | 14.3 | >0.999 |
Positive | 66.7 | 6.5 | 33.3 | 58.3 | 51.1 | 66.0 | 36.6 | 11.4 | |||||||||
Regional lymph nodes | Negative | 64.3 | 0.342 | 9.3 | >0.999 | 36.4 | >0.999 | 61.4 | 0.771 | 55.8 | 0.558 | 72.1 | 0.533 | 35.0 | 0.749 | 11.9 | >0.999 |
Positive | 80.0 | 6.7 | 37.5 | 56.2 | 43.7 | 62.5 | 42.9 | 13.3 | |||||||||
Metastatic occurrence | Negative | 66.7 | 0.108 | 4.6 | 0.502 | 26.7 | 0.032* | 51.1 | 0.092 | 50.0 | >0.999 | 70.4 | 0.473 | 30.8 | 0.171 | 4.8 | 0.003* |
Positive | 90.9 | 9.1 | 63.6 | 81.8 | 45.4 | 54.5 | 54.5 | 45.4 | |||||||||
Local relapse | Negative | 70.8 | >0.999 | 4.1 | 0.257 | 31.4 | 0.323 | 56.9 | >0.999 | 48.0 | 0.669 | 70.0 | 0.316 | 35.6 | >0.999 | 14.6 | 0.601 |
Positive | 80.0 | 20.0 | 60.0 | 60.0 | 60.0 | 40.0 | 40.0 | 0.0 | |||||||||