Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García-Rivello, Hernán; Wernicke, Alejandra; Feldman, Leonardo; Matas, Ayelén; Giorello, María Belén; Borzone, Francisco Raúl; Choi, Hosoon; Howard, Scott C.; Chasseing, Norma Alejandra

doi:10.1186/s12885-017-3259-8

Table 2 Association of the levels of expression of OPG, TRAIL, RANKL, SDF-1, IL-6, and CCL-2 in TEpCs with the clinicopathological characteristics of patients with early invasive

From: Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Characteristics		Ligands in TEpC
		OPG		TRAIL		RANKL		SDF-1		IL-6		CCL-2
		High expression %	p	High expression %	p	High expression %	p	High expression %	p	High expression %	p	High expression %	p
Age (years)	<50	10.0	>0.999	2.2	0.657	70.0	>0.999	40.0	0.153	22.2	0.464	22.2	0.110
Age (years)	≥50	15.7	>0.999	16.0	0.657	73.1	>0.999	67.3	0.153	39.2	0.464	4.1	0.110
Tumor size (cm)	<2	13.9	>0.999	17.1	>0.999	65.9	0.114	70.4	0.044*	42.9	0.236	7.3	>0.999
Tumor size (cm)	≥2	11.8	>0.999	17.6	>0.999	88.2	0.114	41.2	0.044*	23.5	0.236	6.2	>0.999
Histological grade	G1	20.0	0.713	21.4	0.744	46.7	0.073	80.0	0.093	42.9	0.307	6.7	0.357
	G2	10.0		20.0		80.9		66.7		45.0		0.0
	G3	12.5		13.0		79.2		45.8		25.0		13.0
HER2/neu status	Negative	8.1	0.239	18.9	0.733	76.3	0.388	63.2	>0.999	39.5	0.780	2.9	0.287
HER2/neu status	Positive	21.7	0.239	14.3	0.733	65.2	0.388	60.9	>0.999	33.33	0.780	13.6	0.287
ER status	Negative	13.3	>0.999	7.7	0.429	80.0	0.523	40.0	0.064	42.9	0.753	20.0	0.049*
ER status	Positive	13.3	>0.999	20.0	0.429	69.6	0.523	69.6	0.064	35.6	0.753	2.4	0.049*
PR status	Negative	14.3	>0.999	8.3	0.444	78.6	0.737	50.0	0.351	38.5	>0.999	7.1	>0.999
PR status	Positive	13.0	>0.999	19.6	0.444	70.2	0.737	66.0	0.351	37.0	>0.999	7.0	>0.999
Regional lymph nodes	Negative	11.6	0.666	25.0	0.048*	67.4	0.352	58.1	0.555	39.0	0.761	4.7	0.349
Regional lymph nodes	Positive	20.0	0.666	0.0	0.048*	81.2	0.352	68.7	0.555	31.2	0.761	14.3	0.349
Metastatic occurrence	Negative	20.9	0.180	21.4	0.664	70.4	0.707	59.1	>0.999	30.2	>0.999	2.4	0.109
Metastatic occurrence	Positive	18.2	0.180	10.0	0.664	81.8	0.707	63.6	>0.999	40.0	>0.999	18.2	0.109
Local relapse	Negative	6.1	0.330	20.8	0.576	70.0	0.307	60.0	>0.999	38.8	0.284	4.3	0.266
Local relapse	Positive	20.0	0.330	0.0	0.576	100.0	0.307	60.0	>0.999	0.0	0.284	20.0	0.266

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ISSN: 1471-2407

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