Toxicity | Induction therapy CapeOX + BEV (N = 52) | Maintenance therapy Capecitabin + BEV (N = 45) | Reintoroduction therapy CapeOX + BEV (N = 29) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All grade | ≥Grade 3 | All grade | ≥Grade 3 | All grade | ≥Grade 3 | |||||||
n | % | n | % | n | % | n | % | n | % | n | % | |
Hematologic toxiciy | 20 | 38.5 | 5 | 9.6 | 12 | 26.7 | 3 | 6.7 | 11 | 37.9 | 2 | 6.9 |
Neutropenia | 10 | 19.2 | 4 | 7.7 | 4 | 8.9 | 2 | 4.4 | 4 | 13.8 | 2 | 6.9 |
Thrombocytopenia | 9 | 17.3 | 0 | 0 | 8 | 17.8 | 1 | 2.2 | 8 | 27.6 | 0 | 0 |
Anemia | 9 | 17.3 | 0 | 0 | 4 | 8.9 | 0 | 0 | 3 | 7.1 | 0 | 0 |
Febrile neutropenia | 1 | 1.9 | 1 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Non-hematologic toxicity | 44 | 84.6 | 8 | 15.4 | 36 | 80.0 | 6 | 13.3 | 22 | 75.9 | 6 | 20.7 |
Diarrhea | 7 | 13.5 | 1 | 1.9 | 2 | 4.4 | 0 | 0 | 2 | 6.9 | 0 | 0 |
Nausea/vomiting | 8 | 15.4 | 0 | 0 | 2 | 4.4 | 0 | 0 | 3 | 10.3 | 0 | 0 |
Mucositis | 8 | 15.4 | 0 | 0 | 2 | 4.4 | 0 | 0 | 2 | 6.9 | 0 | 0 |
Hand-foot syndrome | 33 | 63.5 | 1 | 1.9 | 22 | 48.9 | 4 | 8.9 | 16 | 55.2 | 3 | 10.3 |
Fatigue | 0 | 0 | 0 | 0 | 1 | 2.2 | 0 | 0 | 1 | 3.4 | 0 | 0 |
Peripheral neuropathy | 26 | 50.0 | 1 | 1.9 | 17 | 37.8 | 0 | 0 | 14 | 48.3 | 2 | 6.9 |
Allergy | 2 | 3.8 | 1 | 1.9 | 0 | 0 | 0 | 0 | 3 | 10.3 | 2 | 6.9 |
BEV-related toxicities | 14 | 26.9 | 1 | 1.9 | 17 | 37.8 | 1 | 2.2 | 11 | 37.9 | 1 | 3.4 |
Hypertension | 9 | 17.3 | 0 | 0 | 11 | 24.4 | 0 | 0 | 8 | 27.6 | 0 | 0 |
Proteinuria | 6 | 11.5 | 0 | 0 | 5 | 11.1 | 0 | 0 | 3 | 10.3 | 1 | 3.4 |
Bleeding | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.4 | 0 | 0 |
Infection | 1 | 1.9 | 0 | 0 | 2 | 4.4 | 1 | 2.2 | 1 | 3.4 | 0 | 0 |
Thrombosis | 1 | 1.9 | 1 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |