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Table 4 Efficacy analysis by timing of CIN during first-line chemotherapy

From: Timing of chemotherapy-induced neutropenia predicts prognosis in metastatic colon cancer patients: a retrospective study in mFOLFOX6 -treated patients

 

All patients

Landmark patients

Timing of CIN

ORR

P value

DCR

P value

ORR

P value

DCR

P value

Early-onset CIN (%)

55.3 (78/141)

<0.001

87.9 (124/141)

<0.001

59.2 (77/130)

<0.001

92.3 (120/130)

<0.001

Late-onset CIN (%)

45.0 (18/40)

 

82.5 (33/40)

 

46.9 (15/32)

 

84.4 (27/32)

 

Absence (%)

17.4 (19/109)

 

49.5 (54/109)

 

18.6 (13/70)

 

54.3 (38/70)