Table 3 Univariable and multivariable analyses of potential prognostic factors in SCLC patients

Gender

-

-

-

0.118

 Female

1 (Referent)

-

1 (Referent)

-

-

 Male

0.89

.66–1.20

0.74

0.51–1.08

-

Age (years)

-

0.597

 ≤ 60

1 (Referent)

-

1 (Referent)

-

-

 > 60

1.08

0.89–1.30

1.05

0.87–1.27

-

Cancer-stage

-

<0.001

 limited stage

1 (Referent)

-

1 (Referent)

-

-

 Extensive stage

2.39

1.97–2.90

2.30

1.88–2.81

-

Smoking status

-

0.126

 Never

1 (Referent)

-

1 (Referent)

-

-

 Current or Ever

1.22

0.95–1.57

1.28

0.93–1.76

-

PS

-

<0.001

 0

1 (Referent)

-

1 (Referent)

-

-

 1

1.04

0.85–1.27

0.98

0.80–1.19

-

 2

3.79

2.64–5.40

3.62

2.52–5.20

-

Chemotherapy

-

0.96

 Etoposide-based

1 (Referent)

-

1 (Referent)

-

-

 Others

1.50

0.21–10.81

1.05

0.15–7.63

-

PCI

-

0.011

 Yes

1 (Referent)

-

1 (Referent)

-

-

 No

1.46

1.15–1.84

1.38

1.08–1.77

-

TRT

-

0.007

 Yes

1 (Referent)

-

1 (Referent)

-

-

 No

1.73

1.42–2.11

1.34

1.08–1.66

-

LDL

-

0.019

 Low

1 (Referent)

-

1 (Referent)

-

-

 Intermediate

1.73

1.22–2.45

1.42

1.00–2.03

-

 High

1.81

1.28–2.58

1.64

1.15–2.35

-

LDLR

-

0.027

 Low

1 (Referent)

-

1 (Referent)

 High

1.61

1.11–2.34

1.54

1.05–2.26