TY - JOUR AU - Jovanović, Bojana AU - Sheng, Quanhu AU - Seitz, Robert S. AU - Lawrence, Kasey D. AU - Morris, Stephan W. AU - Thomas, Lance R. AU - Hout, David R. AU - Schweitzer, Brock L. AU - Guo, Yan AU - Pietenpol, Jennifer A. AU - Lehmann, Brian D. PY - 2017 DA - 2017/04/04 TI - Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue JO - BMC Cancer SP - 241 VL - 17 IS - 1 AB - Triple negative breast cancer (TNBC) is a heterogeneous disease that lacks unifying molecular alterations that can guide therapy decisions. We previously identified distinct molecular subtypes of TNBC (TNBCtype) using gene expression data generated on a microarray platform using frozen tumor specimens. Tumors and cell lines representing the identified subtypes have distinct enrichment in biologically relevant transcripts with differing sensitivity to standard chemotherapies and targeted agents. Since our initial discoveries, RNA-sequencing (RNA-seq) has evolved as a sensitive and quantitative tool to measure transcript abundance. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-017-3237-1 DO - 10.1186/s12885-017-3237-1 ID - Jovanović2017 ER -